DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and PDZD7

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	273	Identity:	59/273 - (21%)
Similarity:	88/273 - (32%)	Gaps:	92/273 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRS-SASASFSRPAFWKVPGYELPTSYRPQPTPKPPLV------------PLPSP---------- 45
            ||| |.|.|.|.....|.||...|:   |.|||.|.:.            |||.|
Human   774 SRSRSRSRSRSSRGQGKSPGRRSPS---PVPTPAPSMTNGRYHKPRKARPPLPRPLDGEAAKVGA 835

  Fly    46 ---------------CRRRSSSGLKKRVHFAD-EQNVGVQVGS----------------PAHGEL 78
                           ...::.||..|.|..:. :|::|:.:..                |.....
Human   836 KQGPSESGTEGTAKEAAMKNPSGELKTVTLSKMKQSLGISISGGIESKVQPMVKIEKIFPGGAAF 900

  Fly    79 LRG------DIISKIGEYDARDLSHADA----QQLFRGAGNE-IRLVVHRDNKIAYTQGATQEAG 132
            |.|      ::::..|| :...::|..|    ::.:|....| :.|||.       ..|.:....
Human   901 LSGALQAGFELVAVDGE-NLEQVTHQRAVDTIRRAYRNKAREPMELVVR-------VPGPSPRPS 957

  Fly   133 PGSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQLP-VDTLPQT---------VFPQLNSSG 187
            |...|..|...:..|.:|...|....|.|:|:     || ..|.|||         ..|....|.
Human   958 PSDSSALTDGGLPADHLPAHQPLDAAPVPAHW-----LPEPPTNPQTPPTDARLLQPTPSPAPSP 1017

  Fly   188 GYEVPSTVFSPKP 200
            ..:.|.:..:|.|
Human  1018 ALQTPDSKPAPSP 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/73 (14%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464
		HN_PDZD7_like	554..630	CDD:259824
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864		23/92 (25%)
		PDZ_signaling	860..948	CDD:238492	15/88 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033		24/100 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900