DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Grip1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	445	Identity:	78/445 - (17%)
Similarity:	134/445 - (30%)	Gaps:	146/445 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VQVGSPA--HGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRD------------ 118
            |:.|.||  .|.:..||.:..:........:||:|..:.:..|.|..|::..|
Mouse   242 VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEATLLIEYDVSVMDSVATASG 306

  Fly   119 ---NKIAYTQGAT---------------------QEAGPGSRSN--------------------- 138
               .::|.|.||:                     :.|....|..
Mouse   307 PLLVEVAKTPGASLGVALTTSVCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTL 371

  Fly   139 --------STLPPVTPDLMPHRGPSPFLPGPSH--FERA-LQLPVDTLPQTVFPQLNSSGGYEVP 192
                    :|...|..:::||......|.||.|  .:|: .|.|.|....      |..|.:
Mouse   372 AEATQFLANTTDQVKLEILPHHQTRLALKGPDHVKIQRSDRQHPWDAWAS------NQCGVH--- 427

  Fly   193 STVFSPKPTRDHQQDVDEEQAAIVNQPYRTTPLVL----PGAKVKKDAPTTES-------YLRHY 246
                    |..|......:...:   |..|.|..|    |.|.|...:||:.|       .:...
Mouse   428 --------TNHHHNTYHPDHCRV---PALTFPKALPPNSPPAMVPSSSPTSMSAYSLSSLNMGTL 481

  Fly   247 PNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADT----GRVFHKQFNSPI---------GLY 298
            |.......|    ..::|::|:........:...:.|    |:|.|.:....:         |:.
Mouse   482 PRSLYSTSP----RGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQ 542

  Fly   299 SNNNI--EDTIRSTVPFATSESNRLKDSPLHRPLPTKLNGYKKTVQYDPRNSETYRAIQEEGGYS 361
            ...::  .:|:.|....:..|:    |||..|....::......:...|....|:    ||....
Mouse   543 LQGSVFATETLSSPPLISYIEA----DSPAERCGVLQIGDRVMAINGIPTEDSTF----EEANQL 599

  Fly   362 NYGQSSPQEVTIPVQTKVYQPNRLVPG------KKP----------VSAPVSRPP 400
            ....|...:||:.::..|.:  .::|.      |.|          :|:|.||.|
Mouse   600 LRDSSITSKVTLEIEFDVAE--SVIPSSGTFHVKLPKKHSVELGITISSPSSRKP 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	13/48 (27%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	14/84 (17%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492
		PDZ_signaling	209..292	CDD:238492	13/49 (27%)
		PDZ_signaling	307..390	CDD:238492	8/82 (10%)
		PDZ_signaling	526..614	CDD:238492	15/95 (16%)
		PDZ_signaling	627..711	CDD:238492	7/26 (27%)
		PDZ_signaling	727..808	CDD:238492
		PDZ_signaling	1058..1138	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900