DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Whrn

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	368	Identity:	79/368 - (21%)
Similarity:	113/368 - (30%)	Gaps:	105/368 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KVPGYELPTSYRPQPTPKPPLVPLPSPCRRRSSSGLKKRVHFADEQNVGVQVGSPAHGELLRGDI 83
            |.|..:|| ..:| |.|.|||                                :..|..||...
Mouse   582 KSPSEDLP-GIKP-PPPPPPL--------------------------------AQGHDRLLGQP- 611

  Fly    84 ISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSNSTLPPVTPDL 148
             .|.|..|...||.|        |.:.|.....|:.  :...|.....||.|..:|...|:...:
Mouse   612 -RKPGREDPAPLSSA--------AHSGIVFSAPRNR--SPPPGTAPTPGPSSAQDSPSSPIYASI 665

  Fly   149 MPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVP--STVFSPKPTRDHQQDVDEE 211
             .|..||...|..:|.....|.|:...|:...|....|...|.|  .....|....:|...|...
Mouse   666 -SHANPSSRKPLDTHLALVNQHPIGPFPRVQSPPHLKSPPAETPGAGACLPPPSPSEHPDAVGAN 729

  Fly   212 QAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKV 276
            |..::.:.:|               |.:|..:..     |||.|         :.|.|.|:
Mouse   730 QHFVLVEVHR---------------PDSEPDVNE-----VRALP---------QTRTASTL---- 761

  Fly   277 VGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTV----PFATSESNRLKDSPLHRPLPTKLNGY 337
             ...:|:|:...:......|        :|..||.    ..|::::...|:.|  |...|.....
Mouse   762 -SQLSDSGQTLSEDSGVDAG--------ETEASTSGRGRQTASAKNKNGKEQP--RTERTAEGAN 815

  Fly   338 KKTVQYDP-------RNSETYRAIQEEGGYSNYGQSSPQEVTI 373
            |.....:|       |.|.....|..||| :|..|..|:.|||
Mouse   816 KPPGLLEPTSTLVRVRKSAATLGIAIEGG-ANTRQPLPRIVTI 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	11/46 (24%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	15/84 (18%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822
		PDZ_signaling	139..216	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266
		PDZ_signaling	278..358	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407
		HN_L-whirlin_R2_like	420..500	CDD:259823
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		66/332 (20%)
		PDZ_signaling	827..898	CDD:238492	12/32 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900