DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Pard3b

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	375	Identity:	78/375 - (20%)
Similarity:	112/375 - (29%)	Gaps:	115/375 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 GELLR-----GDIISKIGEYDARDLSHADAQQLFRGAGNEIRL-VVHRDNKIAYTQG----ATQE 130
            |.:||     .|.:.|..:..|:...|.:.::|.|......|: ..|::.:....:|    ||..
Mouse   908 GAMLRFGKKKDDKVGKAEQKGAQKSGHPEEEELERMKEERERIGAKHQELREKQARGLVDYATAV 972

  Fly   131 AGP------------GSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQL 183
            .||            .:|.|....|.. .....|.|||...||      |..|.|..|
Mouse   973 TGPVHDMDDDEMDPNYARVNHFREPCA-SANVFRSPSPLRAGP------LAYPRDGRP------- 1023

  Fly   184 NSSGGYEVPSTVFSPKPTRDHQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPN 248
                        .||    ||.:.:    .|.||:||....|...|..:.......:...:.|..
Mouse  1024 ------------LSP----DHLEGL----YAKVNKPYHPPALADSGRPMAGTTDRIQKLRKEYYQ 1068

  Fly   249 PAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFN--------------------- 292
              .|......|.|...:.|.:|..|..|.|...| |...:.:|.
Mouse  1069 --ARREGFLLYEDENTRARPSDHDLRWVSGKGPD-GSTHNLRFEGMERQYASLPRGGSADPVDYL 1130

  Fly   293 --SPIGLYSNNNIEDTIRSTVPFATSESNRLKDSPLH-------RPLPTKLNGYKKTVQYDPRNS 348
              ||.|.|::..:        |:...      ..|:|       ||...:....:....|.|.
Mouse  1131 TASPRGRYNDREL--------PYYPG------PHPVHAPRGSYPRPPDLRATDLRYPQYYPPP-- 1179

  Fly   349 ETYRAIQEEGGY-SNYGQSSPQEVTIPVQTKVYQP-NRLVP-GKKPVSAP 395
               .|.|.:|.: .:...|.||...:|    |||. .|..| |..|...|
Mouse  1180 ---PAHQHKGPFRQDVPPSPPQHQRVP----VYQEMGRAGPRGSSPDQYP 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/44 (23%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	14/103 (14%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492
		PDZ	415..504	CDD:214570
		PDZ_signaling	536..624	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900