DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Dlg5

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	507	Identity:	100/507 - (19%)
Similarity:	164/507 - (32%)	Gaps:	151/507 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SFSRPAFWKVPGYELP---TSYRPQPTPKPPLVPLPSPCRRRSSSGLKKRVHFADEQNVGVQVGS 72
            :|.||.......|.||   .::.|||:.:...:..|.|.||..|...:.|:..:.|....:...|
Mouse   988 TFKRPQTPPKIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATLVGSS 1052

  Fly    73 PAHGELLRGDIISKIGEYDARDLSHADAQQLFR----------GAGNEIRLVVHRDNKIAYTQGA 127
            |:     .....:.....|..:.:||...:..|          |.|:...|...:......|...
Mouse  1053 PS-----TSPPSAPPPSMDPSEPTHASPPRKARVRIASSYHSEGDGDTSYLPAKKPCDEDLTSQK 1112

  Fly   128 TQEAGPGSRSNSTLPPVTPDLMPHRGP-----------------------SPFLPG-PSHFERAL 168
            ..|.|...|...:.|...|.:.|...|                       ||:.|| .|.....|
Mouse  1113 VDELGQKRRRPKSAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHASRHGNPL 1177

  Fly   169 QLP----VDTLPQTVFPQLNSSGGYEVPSTVFSPKPT-RDHQQDVDEEQAAIVNQPYRTTPLVLP 228
            ..|    |.|:|:::.|      |..|.|.:.:|..| |.|:                    |||
Mouse  1178 LYPNRPSVGTVPRSMTP------GTTVGSILRNPIYTVRSHR--------------------VLP 1216

  Fly   229 --GAKVKKDAPTTESYLRHYPNPAVRAHPGH-----------DYHD------------------- 261
              ...|.:||.:...      :|:|: |.|.           ||.:
Mouse  1217 CGSPPVPRDAGSQSL------SPSVQ-HQGRLSLDLSHRACSDYSEMRASQGSNSLPSSARLGSS 1274

  Fly   262 ---SIMKQRVADTML----HKVVGSEADTGRVFHKQFNSP------IGLYSNNNIEDTIRSTVP- 312
               ....:|:...:.    ..|:||  |.|.:.|.:.::|      |...|:.:...|..||:|
Mouse  1275 SNLQFKAERIKIPLTPRYPRSVMGS--DRGSLSHSECSTPPRSPLNIDTLSSCSQPQTTASTLPR 1337

  Fly   313 ---FATSESNRLKDSP-LHRPLPTK------------LNGYKKTVQYDPRNSETYRAIQEEGGYS 361
               ..:|...|.||.| :..|...|            ::|.|..|..   :..|..:|..:.|.
Mouse  1338 IAVNPSSHGERRKDRPFVEEPRHVKVQKGSEPLGISIVSGEKGGVYV---SKVTLGSIAHQAGL- 1398

  Fly   362 NYGQSSPQEVTIPVQTKVYQPNRLVPGKKPVSAPV---SRPPYNVVNTHDEN 410
            .||....:...|.:::...|..||:.|::..:..:   ..|..:.:|:|..:
Mouse  1399 EYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHIHQLNSHSRS 1450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	9/56 (16%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	20/96 (21%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492
		PDZ_signaling	<741..800	CDD:238492
		PDZ	1357..1439	CDD:214570	15/85 (18%)
		dbPDZ_assoc	1437..1512	CDD:374667	3/14 (21%)
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900