DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and SHOX2

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_003021.3	Gene:	SHOX2 / 6474	HGNCID:	10854	Length:	355	Species:	Homo sapiens

Alignment Length:	176	Identity:	36/176 - (20%)
Similarity:	58/176 - (32%)	Gaps:	49/176 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 EAGPGSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPST 194
            :.|...||..   |.:|.|...|..    |..:..:..|.||.:.....|.|:|
Human    98 DMGAAERSRE---PGSPRLTEGRRK----PTKAEVQATLLLPGEAFRFLVSPEL----------- 144

  Fly   195 VFSPKPTRDHQQDV----DEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHP 255
                   :|.::|.    ||.|..|..:..||...:....::::....|     |||:..:|...
Human   145 -------KDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDET-----HYPDAFMREEL 197

  Fly   256 GHD-----------YHDSIMKQRVADTMLHKVV----GSEADTGRV 286
            ...           :.:...|.|..:..|||.|    .|:.:..||
Human   198 SQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRV 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	2/2 (100%)
SHOX2	NP_003021.3	Homeobox	167..220	CDD:306543	8/57 (14%)
SHOX2	NP_003021.3	OAR	335..351	CDD:309087
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030