DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Pdlim5

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006233474.1	Gene:	Pdlim5 / 64353	RGDID:	621076	Length:	624	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	89/490 - (18%)
Similarity:	158/490 - (32%)	Gaps:	173/490 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSR 136
            |.||..:  ||::..|....|:.::|.:||...:.....:.:.:.|.:..|.::....:.|....
  Rat    40 SQAHVRI--GDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVAVQKGEPKE 102

  Fly   137 SNSTLPPVTP---------DLMPHRGPSPF----------LPGPS------HFERALQLPVDTLP 176
            ....:|..:|         ::..::.|.||          :|.||      |...:.......:.
  Rat   103 VVKPVPITSPAVSKVTSTTNMAYNKVPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSHASPPPVA 167

  Fly   177 QTVFPQLNSSGGY-----------EVPST----VFSPK-PT-----------------RDHQQDV 208
            ....|.|::||.:           ..|:|    |..|: ||                 |..|.|:
  Rat   168 AVTPPPLSASGLHASANPSAAQCSSPPNTGKPAVHVPRQPTVTSVCSESAQELAEGQRRGSQGDI 232

  Fly   209 DEEQAAIVNQPYRTTPLVLPG-AKVKKDAP--------TTESYLRHYPNPAVRAHPGHDYHDSIM 264
            .::...             || .|:....|        .||.|  |.|.          :.|:..
  Rat   233 KQQNGN-------------PGTVKIPPKRPPRKHIVERNTEFY--HIPT----------HSDASK 272

  Fly   265 KQRVADT----------------MLHKVVGSEADTGRVFH-KQFNSPIGLYSNNNIEDTIRSTVP 312
            |:.:.||                :|.::.|:|       | |:..:.....:|:..|.:.:|..|
  Rat   273 KRLIEDTEDWRPRTGTTQSRSFRILAQITGTE-------HLKESENDNAKKANSTPEPSQQSASP 330

  Fly   313 FATSESNRLKDSPLHRPLPTKLNGYKKTVQYDPRNSETYRA------------------------ 353
            .:.:||  |:....:||:   :.|.:....:.|..|.:.::
  Rat   331 LSAAES--LESPGSNRPV---VAGLRSAAAFKPVGSTSVKSPSWQRPNQAGTSMRKCGDVRSQHT 390

  Fly   354 -------IQEEGGYSNYGQSS----PQEVTI-PVQ-----TKVYQPNRLVPGKK-PVSAPVS--- 397
                   ....|..||...||    |.:..: |.|     |.|.:...:..||: |:.|..:
  Rat   391 QICFGSKAPSTGRISNSASSSGTGAPMKPAVGPPQPSDQDTLVQRAEHIPAGKRTPMCAHCNQAI 455

  Fly   398 RPPYNVV---NTHDENIRQSGSFNRLMYSVIGATE 429
            |.|:.|.   :.|.|....:...|.:.|  ||..|
  Rat   456 RGPFLVALGKSWHPEEFNCAHCKNTMAY--IGFVE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/42 (24%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	14/105 (13%)
Pdlim5	XP_006233474.1	PDZ_signaling	10..82	CDD:238492	10/43 (23%)
		DUF4749	214..305	CDD:292558	19/122 (16%)
		LIM1_ENH	448..499	CDD:188837	11/43 (26%)
		LIM	507..558	CDD:295319
		LIM	566..620	CDD:295319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5207
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.150