DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp66 and dlg5a

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	448	Identity:	88/448 - (19%)
Similarity:	142/448 - (31%)	Gaps:	170/448 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSRSSASASFSRPAFWKVPGYELPTSYRPQPTPKPPLVPLPSPCRRRSSSGLKKRVHFADEQNVG 67
            :||.|......|  .|.    |.|...||:|...|.|       |||.:           .||:.
Zfish  1114 SSRKSCEEDIGR--MWA----EEPEVKRPRPKSAPAL-------RRRMT-----------PQNIP 1154

  Fly    68 VQVGSPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAG 132
            :|                ....| :.|....:.:::.|.:.|.    .|| :.:.:.
Zfish  1155 LQ----------------SFQSY-SNDGDSVEQREMLRSSPNR----PHR-HSVGFV-------- 1189

  Fly   133 PGSRSNSTLPPVTPDLMPHRGPSP------FLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEV 191
            |.| .|.||||.:    .|||.:|      .:..|.:..|:.::..:..| ||..|:|....:..
Zfish  1190 PTS-YNGTLPPNS----AHRGLAPCSAVTAVMKNPVYMVRSHRVHTNNCP-TVVSQINQQHTHPS 1248

  Fly   192 P------STVFSPKPTRDHQQDVDEEQA--------------AIVNQPYRTTPLVLPGAKVKKDA 236
            |      |...|.|.:.|:.:.....:|              :..|..|||..:.:|...
Zfish  1249 PQHQGQLSLDLSQKRSTDYSESSRSSRASHGTNSLPSSARLGSSNNLQYRTERIKIPSTP----- 1308

  Fly   237 PTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGL---Y 298
                    .||                          ..::||  |.|.:.|.:.:||..:   .
Zfish  1309 --------RYP--------------------------RSILGS--DRGSLSHSECSSPSLITPPL 1337

  Fly   299 SNNNIEDTIRSTVPFATSESN-------RLKDSPLHRPLPTKLNGYKKTVQYDPRNSETYRAIQ- 355
            |..|:|     |..||:|:|.       |:..|    |:||:.....:....:|||...::..:
Zfish  1338 SPLNLE-----TSSFASSQSQGSISTLPRISVS----PVPTEERRKDRPYLEEPRNVMVHKGAEP 1393

  Fly   356 --------EEGGY---------------SNYGQSSPQEVTIPVQTKVYQPNRLVPGKK 390
                    |.||.               ..||....:...|.::....|..||:.|::
Zfish  1394 LGISIVSGENGGIFVSKVTGGSIAHQAGLEYGDQLLEYNGINLRNATEQQARLIIGQQ 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	5/46 (11%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	20/92 (22%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018
		Takusan	128..211	CDD:282652
		Taxilin	295..627	CDD:286771
		RILP-like	338..460	CDD:304877
		SH3BP5	444..648	CDD:283045
		PDZ_signaling	696..783	CDD:238492
		PDZ_signaling	793..866	CDD:238492
		PDZ	1381..1463	CDD:214570	13/71 (18%)
		dbPDZ_assoc	1461..1541	CDD:293216
		PDZ	1541..1623	CDD:214570
		SH3_DLG5	1639..1701	CDD:212794
		Guanylate_kin	1780..1949	CDD:279019
		NK	1794..1950	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900