DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Pdlim5

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006501801.1	Gene:	Pdlim5 / 56376	MGIID:	1927489	Length:	734	Species:	Mus musculus

Alignment Length:	399	Identity:	76/399 - (19%)
Similarity:	130/399 - (32%)	Gaps:	108/399 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSR 136
            |.||..:  ||::..|....|:.::|.:||...:.....:.:.:.|.:..|.::..:.:.|....
Mouse    40 SQAHVRI--GDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVSVQKGEPKE 102

  Fly   137 SNSTLPPVTP---------DLMPHRGPSPF--LPGPSHFERALQLPVDTLPQTVFPQLNSSGGYE 190
            ....:|..:|         ::..::.|.||  :..|.         |.::|.
Mouse   103 VVKPVPITSPAVSKVTSTTNMAYNKAPRPFGSVSSPK---------VTSIPS------------- 145

  Fly   191 VPSTVFSP--KPTRDHQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPN---PA 250
             ||:.|:|  ..|..|........|         |||.|..:.:...|..:.......||   ||
Mouse   146 -PSSAFTPAHAATSSHASPTPVAAA---------TPLHLSASGLHVSANLSADQCSSPPNTGKPA 200

  Fly   251 VRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPFAT 315
            |.. |......|:..:...:....:..||:.|.     ||.|...|         |::
Mouse   201 VNV-PRQPTVTSVCSESAQELAEGQRRGSQGDI-----KQQNGNPG---------TVK------- 243

  Fly   316 SESNRLKDSPLHRP--------------LPTKLNGYKK-----TVQYDPR----NSETYRAIQEE 357
                    .|..||              :||..:..||     |..:.||    .|.::|.:.:.
Mouse   244 --------IPPKRPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI 300

  Fly   358 GGYSNYGQSSPQEVTIPVQTKVYQ--PNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFNRL 420
            .|..:..:|......   :.|.|.  .:.|..|..|.:||.....::.|....:......|.:|.
Mouse   301 TGTEHLTESENDNTK---KAKFYSSLEDPLKNGPHPPAAPQLLKVHSQVAIVSKEAATYSSVSRS 362

  Fly   421 MYSVIGATE 429
            ..:|.||.|
Mouse   363 TRTVEGALE 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/42 (24%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	17/96 (18%)
Pdlim5	XP_006501801.1	PDZ_signaling	10..82	CDD:238492	10/43 (23%)
		PHA03307	150..>540	CDD:223039	53/264 (20%)
		DUF4749	214..315	CDD:374237	22/129 (17%)
		LIM1_ENH	558..609	CDD:188837
		LIM2_ENH	617..668	CDD:188841
		LIM3_ENH	676..730	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I5305
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.180