DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and lnx1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	315	Identity:	62/315 - (19%)
Similarity:	108/315 - (34%)	Gaps:	115/315 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LKKRVHFADEQNVGVQ-VGSP-AHG----ELLRGDIISKIGE------------YDARDLSHADA 100
            |.||   |.::.:|:: |..| .||    .||.|.:.::.|.            :|.|..:...|
Zfish   415 LVKR---APDEQLGIKLVRRPDEHGVFIFHLLEGGLAARDGRLRVDDRVLAINGHDLRYGAPEHA 476

  Fly   101 QQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSNSTLPPVTPDLMPH-----RGPSPFLP- 159
            ..|.:.:.:.:..:|.|...|.                      .||::..     .||.|:.|
Zfish   477 ALLIQASEDRVHFIVSRQTHIP----------------------APDILQEAPWNMEGPPPYSPV 519

  Fly   160 -----------GPSHFERALQL---PVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQD--- 207
                       .|:.:|:.:.|   |.|:|..||...: ||.|:::|..|.:..|.....|:
Zfish   520 DIEHTLLDSCQKPACYEKTVTLLKEPHDSLGMTVAGGM-SSRGWDLPVYVTNVDPNGVVGQEGSI 583

  Fly   208 -----------VD----EEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYL-----RHYPNPAVR 252
                       ||    ....|:.|....::|:||   :|.:..|..||.|     .|.|.....
Zfish   584 RKGDILLNVNGVDLTGVTRSEAVANLKNTSSPVVL---QVLEMRPPNESSLDCMPPLHSPCALSP 645

  Fly   253 AHPG--------HDY-----------------HDSIMKQRVADTMLHKVVGSEAD 282
            :.||        .||                 .|.::::..:.::...:||.:.:
Zfish   646 SSPGDVKLPPPNDDYAPLWVSWLQLPRHLYCCKDIVLRRSTSGSLGFSIVGGQEE 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	12/64 (19%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492
		PDZ_signaling	411..491	CDD:238492	17/78 (22%)
		PDZ_signaling	536..621	CDD:238492	21/88 (24%)
		DegQ	<548..621	CDD:223343	17/76 (22%)
		PDZ_signaling	678..762	CDD:238492	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900