DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and lhx8

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_012816489.1	Gene:	lhx8 / 548653	XenbaseID:	XB-GENE-494997	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	242	Identity:	46/242 - (19%)
Similarity:	73/242 - (30%)	Gaps:	77/242 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 KDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGS------EADTGRVFHKQFN 292
            ||......|.|.|.....|.  |...|.:...:|....:.|....:      :..||..|..
Frog   149 KDIYCKLDYFRRYGTRCSRC--GRHIHATDWVRRAKGNVYHLACFACYSCKRQLSTGEEFAL--- 208

  Fly   293 SPIGLYSNNNIEDTIRSTVPF---------ATSESNR-------LKDSPLHRPLPTKLNGYKKT- 340
                      :|:.:...|.:         |....||       |.:..:::|.|.|......|
Frog   209 ----------VEEKVLCRVHYDCMLDNLKRAVENGNRVSVEGALLTEQDINQPKPAKRARTSFTA 263

  Fly   341 ----------VQYDPRNSETYRAIQEEGGYSN-----YGQS---------SP-QEVTIPVQTKVY 380
                      .|.:..:::|.:.:.|..|.|.     :.|:         || ...|.||.|  .
Frog   264 DQLQVMQAQFAQDNNPDAQTLQKLSERTGLSRRVIQVWFQNCRARHKKHVSPNHSSTTPVTT--V 326

  Fly   381 QPNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFNRLMYSVIGA 427
            ||:||            .||.....|:...:.|.|.....::|.:.|
Frog   327 QPSRL------------SPPMLEEMTYSAYVPQDGPMLTALHSYMDA 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	14/100 (14%)
lhx8	XP_012816489.1	LIM1_Lhx7_Lhx8	103..158	CDD:188767	2/8 (25%)
		LIM2_Lhx7_Lhx8	165..219	CDD:188769	10/68 (15%)
		Homeobox	258..311	CDD:365835	7/52 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030