DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Grip

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	82/450 - (18%)
Similarity:	134/450 - (29%)	Gaps:	194/450 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VQVGSPAH--GELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQE 130
            |::|||||  |.|..|||:..:   |...:.|.:...|.:                  .:|.:|.
  Fly   601 VKMGSPAHRSGSLRSGDILLAV---DQHPVQHFNVDALLK------------------EEGRSQN 644

  Fly   131 AGPGSRSNSTLP---PVTPDLMPHRGP----------------------------SPFL------ 158
            ....|...:||.   .|.||.:|...|                            |.::
  Fly   645 PSHSSSDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYA 709

  Fly   159 ---------PGPSHFERALQLPV--DTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQDVDEEQ 212
                     |.|.:|    ::|.  |...|:|  ||.|..|            :....|..:...
  Fly   710 DCVSLKSRTPQPDYF----RVPSMDDASLQSV--QLRSGSG------------SNGGNQAANSWS 756

  Fly   213 AAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYP---NPAVRAHPGHDY--HDSIMKQRVADTM 272
            ..:.::.|     |.|        |.|:|.....|   :...:.:||::.  :.|:....:...|
  Fly   757 TGVNSRSY-----VAP--------PNTQSLTTELPEEEDEQEQMYPGYELNRYASVDCTALPPPM 808

  Fly   273 LHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPFATSESNRLKDSPLHRPLPTKLNGY 337
            .:||.||                                  |.|.|::...|.||:.:
  Fly   809 ENKVYGS----------------------------------AASSSSKSSGSSLHQII------- 832

  Fly   338 KKTVQYDPR---------------NSETYRAIQEEGGYSNYGQ---------------------- 365
             .||:.:|:               .|.|...:.|.|.....||
  Fly   833 -FTVRLEPKGGLLGITLAGSEDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSH 896

  Fly   366 --SSPQEVTIPVQTKVYQPNRL-----VPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFN 418
              |..|.:...|..|:.:.:.|     :|..:.:.|.|.|.|.: .:.:.|..::|||.|
  Fly   897 ATSLLQNLGDLVDLKILRSHDLANGSHLPQTQAIYAKVQRRPRS-PSANTEASKESGSGN 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	14/48 (29%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	12/88 (14%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084
		PDZ_signaling	183..254	CDD:238492
		PDZ_signaling	278..375	CDD:238492
		PDZ	496..>521	CDD:294084
		PDZ_signaling	571..658	CDD:238492	19/77 (25%)
		PDZ_signaling	832..913	CDD:238492	13/88 (15%)
		PDZ_signaling	973..1055	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900