DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and lhx6a

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001004015.1	Gene:	lhx6a / 445565	ZFINID:	ZDB-GENE-041025-1	Length:	375	Species:	Danio rerio

Alignment Length:	195	Identity:	42/195 - (21%)
Similarity:	68/195 - (34%)	Gaps:	69/195 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CRRRSSSG---------LKKRVHF---ADEQNVGVQVGSPAHGELLRGDIISKIGEYD------- 91
            |:|:.|:|         :..|:|:   .:......:.||   |..|.|.:.|   |.|
Zfish   189 CKRQLSTGEEFGLVEEKVLCRIHYDTMVENLKRAAESGS---GLTLEGAVPS---EQDSQPKPAK 247

  Fly    92 ------------------ARDLSHADAQQL-----FRGAGNEIRLVVHRDNKIAYTQGATQEAG- 132
                              |:| ::.|||.|     ..|....:..|..::.:..:.:...|..|
Zfish   248 RARTSFTAEQLQVMQAQFAQD-NNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQHNGP 311

  Fly   133 PGSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFER--ALQLPVDTLPQTV------------FPQL 183
            |.:...:.:||..||.:.:   |||  |.....|  ||...:|:.|.:|            .|||
Zfish   312 PQAHPQARMPPSLPDELHY---SPF--GSPERARMVALHGYIDSHPFSVLTTQSLPHQAMTLPQL 371

Fly 184 183
Zfish 372 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	15/76 (20%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
lhx6a	NP_001004015.1	LIM1_Lhx6	97..150	CDD:188766
		LIM2_Lhx6	158..212	CDD:188768	5/22 (23%)
		Homeobox	250..302	CDD:278475	8/52 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030