DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp66 and Lnx2

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	60/280 - (21%)
Similarity:	100/280 - (35%)	Gaps:	76/280 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KRVHFADEQNVGV----QVGSPAH-GELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVV 115
            |.|...||..|.:    :.|..|. |.|...|.:..|..:|.:..:...|..:.:.:|..:.|.:
  Rat   353 KLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKQGTPELAAHIIQASGERVNLTI 417

  Fly   116 HRDNKIAYTQGATQEAGPGSRSNSTLPPVTPDLMPHRGPSPFLPGPSH---------FERALQL- 170
            .|..|...:.| ::|||..| ||...||      .|..||      ||         .|:.:.:
  Rat   418 ARPGKPQPSNG-SREAGAHS-SNHAQPP------SHSRPS------SHKDLTRCVTCQEKHITVK 468

  Fly   171 --PVDTLPQTVFPQLNSSGGYEVPSTVFSPKP----TRDHQ---------------QDVDEEQAA 214
              |.::|..||.....|..| |:|..|.|..|    .||.:               .::...:|.
  Rat   469 KEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAV 532

  Fly   215 IVNQPYRTTPLVL-------------------PGA--KVKKDAPTTESYLRHYPNPAVRAHPGHD 258
            .:.:....:|.|:                   |||  :.:.||..:.|::.....|:..    |.
  Rat   533 AMLKASAASPAVILKALEVQIAEEAAQATEEQPGAFSENEYDASWSPSWVMWLGLPSAL----HS 593

  Fly   259 YHDSIMKQRVADTMLHKVVG 278
            .||.::::....:....:||
  Rat   594 CHDIVLRRSYLGSWGFSIVG 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/51 (20%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570
		PDZ	335..421	CDD:214570	16/67 (24%)
		PDZ_signaling	462..538	CDD:238492	15/76 (20%)
		PDZ_signaling	595..679	CDD:238492	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900