DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and HOXB8

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_076921.1	Gene:	HOXB8 / 3218	HGNCID:	5119	Length:	243	Species:	Homo sapiens

Alignment Length:	154	Identity:	29/154 - (18%)
Similarity:	53/154 - (34%)	Gaps:	55/154 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQDVDEEQAAIVNQPYRTTPL 225
            |::::......:...|..|:.. :|.|.::.||.:          |:.....:::...||:..|.
Human    21 PNYYDCGFAQDLGGRPTVVYGP-SSGGSFQHPSQI----------QEFYHGPSSLSTAPYQQNPC 74

  Fly   226 VLPGAKVKKDAPTTESYLRHYPNPAVRAH--PGHDY-HDSIMKQ-----------RVADTMLHKV 276
                                    ||..|  ||:.| :|.:.:|           :.||..|...
Human    75 ------------------------AVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAA 115

  Fly   277 --VGSEADTGRVFHKQFNSPIGLY 298
              :|.||:..    :|..||..|:
Human   116 SGLGEEAEGS----EQSPSPTQLF 135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	4/14 (29%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		1/2 (50%)
		Homeobox	150..203	CDD:395001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030