DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Stxbp4

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006247190.1	Gene:	Stxbp4 / 303443	RGDID:	1307903	Length:	557	Species:	Rattus norvegicus

Alignment Length:	259	Identity:	60/259 - (23%)
Similarity:	99/259 - (38%)	Gaps:	52/259 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RSSSGLKKRVHF-----ADEQNVGVQV-------------------GSPAH--GELLRGDIISKI 87
            ||||.|::...|     |.|..:|:::                   |...:  |.|..||.:..|
  Rat     9 RSSSPLERDPAFRVITVAKETGLGLKILGGIDRNEGPLVYIHEVTPGGDCYKDGRLKPGDQLVSI 73

  Fly    88 GEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSNSTLPPVTPDLMPHR 152
            .:.....:|..:|:.:...|    :|......:||:.:..:....||:....: |||:.|..|..
  Rat    74 NKESMIGVSFEEAKNILTRA----KLRWESPLEIAFIRQKSYCGHPGNICCQS-PPVSEDCEPQT 133

  Fly   153 G-----PSP---FLPGPSHFERALQ--LPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRDHQQD 207
            .     .||   .||..|...|...  ||..|:.||. |:.:.:|...|||  .:.:||.....|
  Rat   134 SAFNLLSSPAGTLLPKTSSTPRTQDSILPSCTVIQTQ-PEHSQAGLAPVPS--LNNRPTDTSNAD 195

  Fly   208 VDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADT 271
            :........:.|.....| .|.|::|  |...|..|.:     :...|..:.|:::.:|..||:
  Rat   196 IAPAWTDDASGPQGKISL-NPSARLK--AEKLEMALNY-----LGIQPTKEQHEALRQQVQADS 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/67 (15%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
Stxbp4	XP_006247190.1	PDZ_signaling	21..94	CDD:238492	12/76 (16%)
		TPR_MLP1_2	299..400	CDD:285204
		GBP_C	<306..389	CDD:303769
		coiled coil	359..369	CDD:293879
		coiled coil	378..389	CDD:293879
		WW	502..531	CDD:278809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900