DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and LHX6

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_011516823.1	Gene:	LHX6 / 26468	HGNCID:	21735	Length:	407	Species:	Homo sapiens

Alignment Length:	192	Identity:	37/192 - (19%)
Similarity:	66/192 - (34%)	Gaps:	61/192 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 ERAL-QLPVDTLPQTVFPQLNSSGGYEVPSTVFS-----PKPTRDHQQDVDEEQAAIVNQPYRTT 223
            |:.| ::..||:.:.:.....:..|..:...|.|     |||.:..:.....||..::.
Human   206 EKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSEQDSQPKPAKRARTSFTAEQLQVMQ------ 264

  Fly   224 PLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADT--MLHKVVGSEADTGRV 286
                  |:..:|           .||           |:...|::||.  :..:|:.......|.
Human   265 ------AQFAQD-----------NNP-----------DAQTLQKLADMTGLSRRVIQVWFQNCRA 301

  Fly   287 FHKQFN-----SPIGLYSN---NNIEDTIRSTVPFATSESNRLKDSPLHRPLPTKLNGYKKT 340
            .||:..     .|.|...:   :.:.|.|..| ||::.|..|:          ..|:||.:|
Human   302 RHKKHTPQHPVPPSGAPPSRLPSALSDDIHYT-PFSSPERARM----------VTLHGYIET 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	16/64 (25%)
LHX6	XP_011516823.1	LIM1_Lhx6	99..152	CDD:188766
		LIM2_Lhx6	160..214	CDD:188768	2/7 (29%)
		Homeobox	252..304	CDD:278475	12/85 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030