DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Ldb3

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_036048.3	Gene:	Ldb3 / 24131	MGIID:	1344412	Length:	723	Species:	Mus musculus

Alignment Length:	384	Identity:	68/384 - (17%)
Similarity:	122/384 - (31%)	Gaps:	148/384 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSN 138
            |..:|.:||::..|...:...::|.:||...:.|...:.|.:.:..:            |...|
Mouse    39 AQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKR------------PIPIS- 90

  Fly   139 STLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRD 203
            :|.||:                        |.|:..:|....|.|:::|....||
Mouse    91 TTAPPI------------------------QSPLPVIPHQKDPALDTNGSLATPS---------- 121

  Fly   204 HQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHPG----HDYHDSIM 264
                                                       |:|..||.||    .|...|..
Mouse   122 -------------------------------------------PSPEARASPGALEFGDTFSSSF 143

  Fly   265 KQRVADTMLHKVVG-------------SEADTGRVFHK---------QFNSPIGLYSNNNIED-- 305
            .|....:.|.:..|             ||...|.|..|         |:|:||||||...:.:
Mouse   144 SQTSVCSPLMEASGPVLPLGSPVAKASSEGAQGSVSPKVLPGPSQPRQYNNPIGLYSAETLREMA 208

  Fly   306 -----TIRSTVPFA--TSESNRLKD------SPLHRP-LPTKLNGYKKTVQYDPRN----SETYR 352
                 ::|.....|  ...|..:||      ||:::. :.|:.....:..::..|:    |.::|
Mouse   209 QMYQMSLRGKASGAGLLGGSLPVKDLAVDSASPVYQAVIKTQSKPEDEADEWARRSSNLQSRSFR 273

  Fly   353 AIQEEGGYSNYGQSSPQEV----TIPVQ------TKVYQPNRLVPGKKPVSA-PVSRPP 400
            .:.:..| :.|.|...:|.    :.|::      ::...|......:.|.:| |::..|
Mouse   274 ILAQMTG-TEYMQDPDEEALRRSSTPIEHAPVCTSQATSPLLPASAQSPAAASPIAASP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/40 (25%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	21/102 (21%)
Ldb3	NP_036048.3	PDZ_signaling	5..81	CDD:238492	10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..134		18/122 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..193		6/28 (21%)
		DUF4749	191..293	CDD:374237	23/102 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..423		10/53 (19%)
		PHA03247	<378..528	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..525
		LIM1_ZASP_Cypher	547..598	CDD:188838
		LIM2_Enigma_like	606..657	CDD:188748
		LIM3_ZASP_Cypher	665..719	CDD:188844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	70	1.000	Inparanoid score	I5305
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.180