DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and GRIP1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	450	Identity:	92/450 - (20%)
Similarity:	157/450 - (34%)	Gaps:	107/450 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VPLPSPCRRRSS-----SGLKKRVHFADEQNVGVQVGSPAH--GELLRGDIISKIGEYDARDLSH 97
            :.:.||..|:..     |.:||              ||.||  |.|..||.:..|......:.|.
Human   661 ITISSPSSRKPGDPLVISDIKK--------------GSVAHRTGTLELGDKLLAIDNIRLDNCSM 711

  Fly    98 ADAQQLFRGAGNEIRLVVHRD----------NKIAYTQGATQEAGP-GSRSNSTLPPVTPDLMP- 150
            .||.|:.:...:.::|.:.:|          ..|.||....:..|| |...:.|..|..|.::.
Human   712 EDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISS 776

  Fly   151 -------------HRGP------SPFLPGP--SHFERALQLPVDTLPQTVFPQLNSSGGYEVPST 194
                         |.|.      |..|.|.  |.....||:..:|:...:..|.::       .:
Human   777 LTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDA-------QS 834

  Fly   195 VFSPK--PTRDHQQDVD--EEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAH- 254
            ..|||  |...|..|:.  ||.::...:|.:.:.:      .....|:.:|.:..:...|:...
Human   835 ASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDM------YPSTVPSVDSAVDSWDGSAIDTSY 893

  Fly   255 --PGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVP-FATS 316
              .|..:..|.......|....|..||.:...:. ..|....:||    :.||..|||.. ||.:
Human   894 GTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKP-RSQTYPDVGL----SYEDWDRSTASGFAGA 953

  Fly   317 E------------SNRLKD------SPLHRPL-PTKLNGYKKTVQYD---PRNSETYRAIQEEGG 359
            .            |..|:|      |.:.|.| .|.::|...::.::   ||:....:|..:|..
Human   954 ADSAETEQEENFWSQALEDLETCGQSGILRELEATIMSGSTMSLNHEAPTPRSQLGRQASFQERS 1018

  Fly   360 YS--NYGQSSPQEVTIP--VQTKVYQPNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSG 415
            .|  :|.|:: :..|:|  |..|.....::....|.:.:|.....:.|....|.::...|
Human  1019 SSRPHYSQTT-RSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTLYKDSDMEDFG 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	14/48 (29%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	22/96 (23%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492
		PDZ_signaling	227..310	CDD:238492
		PDZ_signaling	325..408	CDD:238492
		PDZ_signaling	545..633	CDD:238492
		PDZ_signaling	646..730	CDD:238492	20/82 (24%)
		PDZ_signaling	746..827	CDD:238492	17/80 (21%)
		PDZ_signaling	1062..1142	CDD:238492	2/15 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900