DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and PDZD2

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	502	Identity:	99/502 - (19%)
Similarity:	157/502 - (31%)	Gaps:	178/502 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CRRRSSSGLKKRVHFADEQNVGVQVGSPAHG-----ELLRGDIISKIGEYDARDLSHADAQQLFR 105
            |:.:|...|.::|   .|.:.......|:|.     |:.|...::|:..      |.:..|...|
Human  2124 CQEKSEIRLYRQV---AESSTSHPSSLPSHASQAEQEMSRSFSMAKLAS------SSSSLQTAIR 2179

  Fly   106 GAGNEIRLVVHRDNKIAYTQGATQ-------------EAGPGSRSNSTLPPVTPDLMPHRGPSPF 157
                          |..|:||.:.             ..||....:....| .|....:..|:.|
Human  2180 --------------KAEYSQGKSSLMSDSRGVPRNSIPGGPSGEDHLYFTP-RPATRTYSMPAQF 2229

  Fly   158 LPGPSHF------------ERALQLPVDTLPQTVFPQLNSSGGYEVPST-----VFSPKPTRDHQ 205
               .|||            .|..|:||.:   :|.|:..:|.| .:||.     ::|.||..|..
Human  2230 ---SSHFGREGHPPHSLGRSRDSQVPVTS---SVVPEAKASRG-GLPSLANGQGIYSVKPLLDTS 2287

  Fly   206 QDV---DE-------EQAAIV---------------NQPYRTTPLVLPGAKVKK-------DAPT 238
            :::   ||       |.:.:|               |.|:.:|.......::|.       |.|.
Human  2288 RNLPATDEGDIISVQETSCLVTDKIKVTRRHYCYEQNWPHESTSFFSVKQRIKSFENLANADRPV 2352

  Fly   239 TES----YLRHYPNPAV------------RAHPGHDYHDSIMKQRVADTMLHKVVGS----EADT 283
            .:|    :|.....|.:            ..|||.          .|..:|.:.:.|    :::.
Human  2353 AKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHPGD----------AAARLLRRSLSSCSENQSEA 2407

  Fly   284 GRVFHKQFNSPIGLYSNNNIEDTIRSTVPFATS---ESNRLKDS--PLHRPLPT-------KLNG 336
            |.:..:...||      :.:..||....|..||   ..:.||.|  ||..|.||       |.|
Human  2408 GTLLPQMAKSP------SIMTLTISRQNPPETSSKGSDSELKKSLGPLGIPTPTMTLASPVKRN- 2465

  Fly   337 YKKTVQY----------------------DPRNSETYRAIQEEGGYSNYGQSSPQEVTIPVQTKV 379
             |.:|::                      |...||.|.|......:....:.:|:....|....|
Human  2466 -KSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDYSAGPSAVLFKTELEITPRRSPGPPAGGV 2529

  Fly   380 YQP----NRLVPGKKPVSAPVSRPPYNVVNT----HDENIRQSGSFN 418
            ..|    ||..||........:..|.:..:|    .|...|:|.|.|
Human  2530 SCPEKGGNRACPGGSGPKTSAAETPSSASDTGEAAQDLPFRRSWSVN 2576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	8/51 (16%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	24/107 (22%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492
		PDZ_signaling	726..810	CDD:238492
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900