DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Tamalin

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_620249.1	Gene:	Tamalin / 192254	RGDID:	70554	Length:	394	Species:	Rattus norvegicus

Alignment Length:	237	Identity:	41/237 - (17%)
Similarity:	59/237 - (24%)	Gaps:	127/237 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 VHFADEQNV-------GVQVGSPAH-GELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRL- 113
            :|..:||.|       .|...|||. ..|..||.|:.:...:...:.|.:...:.:.:||.:||
  Rat   120 LHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLE 184

  Fly   114 ---------------------------------------VVH----RDNKIAYTQGATQEA---- 131
                                                   :||    :|..|..|..:.:..
  Rat   185 TLYGTSIRKAELEARLQYLKQTLYEKWGEYRSLMVQEQRLVHGLVVKDPSIYDTLESVRSCLYGA 249

  Fly   132 ---------GP------GSRSNS-----------------------TLPPVTPDLMPHRGPSPFL 158
                     ||      |:|..|                       .|||..|   |.|.|.|
  Rat   250 GLLPGSLPFGPLLAAPGGARGGSRRAKGDTDDAVYHTCFFGGAEPQALPPPPP---PARAPGP-- 309

  Fly   159 PGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKP 200
                                        |..|.|::|..|.|
  Rat   310 ----------------------------GSAETPASVLCPAP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	13/87 (15%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
Tamalin	NP_620249.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		PDZ_signaling	99..184	CDD:238492	16/63 (25%)
		Interaction with PSCD3. /evidence=ECO:0000250	180..257		7/76 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..318		11/57 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900