DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Pitx3

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_006526827.1	Gene:	Pitx3 / 18742	MGIID:	1100498	Length:	388	Species:	Mus musculus

Alignment Length:	261	Identity:	51/261 - (19%)
Similarity:	95/261 - (36%)	Gaps:	75/261 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LNS----SGGYEVPSTVFSPKPTRDHQQDVDEE-----QAAIVNQPYRTTPLVLPGAKVKKDAPT 238
            |||    ||.|.:|.     .|:.:.:.::..:     :..::.:....:|     |....||.|
Mouse    55 LNSACHCSGCYPLPG-----PPSTEIEDEIKRQRPPSMEFGLLGEAEARSP-----ALSLSDAGT 109

  Fly   239 TESYLRHYPNPAVRAH--PGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNN 301
                    |:|.:..|  .|.::.||       :.....:.|...:.|.:..||...... :::.
Mouse   110 --------PHPPLPEHGCKGQEHSDS-------EKASASLPGGSPEDGSLKKKQRRQRTH-FTSQ 158

  Fly   302 NIEDTIRSTVPFATSESNRLKDSPLHRPLP--TKLNGYKKTVQYDPRNS---ETYRAIQEE---G 358
            .:::.      .||.:.||..|......:.  |.|...:..|.:..|.:   :..|:.|.|   |
Mouse   159 QLQEL------EATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKG 217

  Fly   359 GYS-----------------NYGQSSPQEVTIPVQTKVYQP---NRLVPGKKPV-SAPVSRPPYN 402
            |::                 :||...|:.:..|:..|.: |   |.:..|  |: |.||..||.:
Mouse   218 GFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTF-PFAFNSVNVG--PLASQPVFSPPSS 279

  Fly   403 V 403
            :
Mouse   280 I 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	14/81 (17%)
Pitx3	XP_006526827.1	Homeobox	152..205	CDD:365835	9/59 (15%)
		PTZ00395	<228..>322	CDD:185594	14/56 (25%)
		OAR	344..361	CDD:367680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030