DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and alp-1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001023371.1	Gene:	alp-1 / 177701	WormBaseID:	WBGene00001132	Length:	1424	Species:	Caenorhabditis elegans

Alignment Length:	446	Identity:	99/446 - (22%)
Similarity:	150/446 - (33%)	Gaps:	123/446 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SYRPQPTPKPPLVPLPSPCRRRSSSGLKK-RVHFADEQNVGV----QVGSP--AHGELLRGDIIS 85
            :|.||.....|:...|:|     |:|.|. ..|:...:..|:    |.|.|  |.|..|...:..
Worm   307 AYHPQVNTARPVSVSPAP-----SAGSKTVTTHYHTPKTQGILSPGQRGVPTAAFGADLSKSVTY 366

  Fly    86 KIG------EYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSNSTLPPV 144
            ..|      .||:..||.|.:|...:.         ...::..|.|...|           .||
Worm   367 GGGVGPGGTHYDSNRLSPAPSQYSTQS---------RNQSQQHYQQHVVQ-----------APP- 410

  Fly   145 TPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQT----VFPQLNSSGGYEVPSTVFSPKPTRDHQ 205
                     |.|..|.||: |:..|..|..||.:    |.|:.:.....:.|....   ||.:..
Worm   411 ---------PVPSNPPPSN-EQQSQSRVQNLPDSVRSAVSPRRSGKSPRQWPPPAM---PTTNRY 462

  Fly   206 QDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPAVRAHP-----GHDYHDSIMK 265
            ..:|...|....:......||   |.:|:...:.|.      .|.|:..|     |.....:|.|
Worm   463 WQIDPADALKKEKVNYGEDLV---ALIKEVEQSKEK------EPKVKKEPKKGTRGARRASNISK 518

  Fly   266 QRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPFATSESNRLKDSPLHRPL 330
            ::|......:...:|....:...|:......|.....:|..:   ||  ||:       ||..|.
Worm   519 EQVQQAFEEQRKRTERKEIKKLEKEIKPKPELKVEVPVEPLV---VP--TSK-------PLEEPC 571

  Fly   331 PTKL------NGYKKTVQYDP--RNSETYR-----AIQEEGG----YSNYGQ--------SSPQE 370
            |..|      :|...||.:.|  |:....:     ||.|..|    ..:|..        |:||
Worm   572 PEALPPPKINDGIHWTVIHSPVLRSPSPAKVTSEAAIPESNGVVKPIPSYASQPIGISKTSTPQ- 635

  Fly   371 VTIPVQ--TKVYQPNRLVPGKKPVSAPVSRP--PYN--------VVNTHDENIRQS 414
               |.:  ::|.:|:....|.|.|.|||..|  |.:        :|.:.|.|:..|
Worm   636 ---PFRPGSQVERPHYSSVGLKDVHAPVPLPRSPQHSPQPVQSYIVRSSDANVTTS 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	13/58 (22%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	20/86 (23%)
alp-1	NP_001023371.1	PDZ_signaling	5..80	CDD:238492
		DUF4749	137..>197	CDD:292558
		ZM	137..162	CDD:128974
		LIM_ALP_like	220..271	CDD:188746
		LIM1_Enigma_like_1	1251..1304	CDD:188839
		LIM	1312..1363	CDD:295319
		LIM3_Enigma_like_1	1371..1424	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.130