DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and Lnx1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	412	Identity:	88/412 - (21%)
Similarity:	141/412 - (34%)	Gaps:	125/412 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRSSASASFSRPAFWKVPGYELPTSYRPQPTPKPPLVPLPSPCRRRSSSGLK--KRVHFADEQNV 66
            |||:|               .:|.||.|:......::...||   ....|:|  :||   ||..|
Mouse   367 SRSNA---------------HVPDSYGPRDDSFHVILNKSSP---EEQLGIKLVRRV---DEPGV 410

  Fly    67 ---GVQVGSPA--HGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRD-------- 118
               .|..|..|  ||:|...|.:..|..:|.|..|...|..|.:.:...:.|||.|.
Mouse   411 FIFNVLNGGVADRHGQLEENDRVLAINGHDLRFGSPESAAHLIQASERRVHLVVSRQVRQSSPDI 475

  Fly   119 -NKIAYTQGATQEAGPGSRSNSTLPPVTPDLMPHRGPSPFLPGPSHFERALQL---PVDTLPQTV 179
             .:..:.....|..|||.|:.::.|..|                .| |:.:.:   |.::|..||
Mouse   476 FQEAGWISNGQQSPGPGERNTASKPAAT----------------CH-EKVVSVWKDPSESLGMTV 523

  Fly   180 FPQLNSSGG-----YEVPSTVFSPKP----TRDHQQDVDEEQAAIVNQPYRTTPLVLPGAKVK-K 234
                  .||     :::|..|.|.:|    :||.:              .:|..::|....:: .
Mouse   524 ------GGGASHREWDLPIYVISVEPGGVISRDGR--------------IKTGDILLNVNGIELT 568

  Fly   235 DAPTTESYLRHYPNPAVRAHPGHDYHDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYS 299
            :...||:.                   :|:|...:..:|..:...|.:.     ::..||..|.|
Mouse   569 EVSRTEAV-------------------AILKSAPSSVVLKALEVKEQEA-----QEDCSPAALDS 609

  Fly   300 NNNIEDTIRSTVPFATSESNRLKDSPLHRPLPTKLNGYKKTVQYDPRNSETYRAIQEEGGYSNYG 364
            |:|:      |.|...|.|     ..:...||..|...|..:.  .||:.........|||..|.
Mouse   610 NHNV------TPPGDWSPS-----WVMWLELPQYLCNCKDVIL--RRNTAGSLGFCIVGGYEEYS 661

  Fly   365 QSSPQEVTIPVQ-TKVYQPNRL 385
            .:.|..:...|: |..|...|:
Mouse   662 GNKPFFIKSIVEGTPAYNDGRI 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	14/48 (29%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	16/73 (22%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220
		NPXY motif	185..188
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244
		PDZ_signaling	276..360	CDD:238492
		PDZ_signaling	384..464	CDD:238492	23/85 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500		5/18 (28%)
		PDZ_signaling	506..589	CDD:238492	19/121 (16%)
		PDZ_signaling	637..721	CDD:238492	12/49 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900