DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and TAMALIN

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_859062.1	Gene:	TAMALIN / 160622	HGNCID:	18707	Length:	395	Species:	Homo sapiens

Alignment Length:	150	Identity:	29/150 - (19%)
Similarity:	42/150 - (28%)	Gaps:	67/150 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PQPTPKPP-LVPLPSP---------------------------CRRRSSSGLKKR---------- 57
            |.|||.|| ....|.|                           ..||..||.:.:
Human    35 PVPTPGPPAAAATPGPPADELYAALEDYHPAELYRALAVSGGTLPRRKGSGFRWKNLSQSPEQQR 99

  Fly    58 ---------------------VHFADEQNV-------GVQVGSPAH-GELLRGDIISKIGEYDAR 93
                                 :|..:||.|       .|...|||. ..|..||.|:.:...:..
Human   100 KVLTLEKEDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPAQLAGLTPGDTIASVNGLNVE 164

  Fly    94 DLSHADAQQLFRGAGNEIRL 113
            .:.|.:...:.:.:||.:||
Human   165 GIRHREIVDIIKASGNVLRL 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	12/46 (26%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
TAMALIN	NP_859062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		8/16 (50%)
		PDZ_signaling	100..185	CDD:238492	16/84 (19%)
		Interaction with PSCD3. /evidence=ECO:0000250	181..258		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900