DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and DMBX1

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001374705.1	Gene:	DMBX1 / 127343	HGNCID:	19026	Length:	382	Species:	Homo sapiens

Alignment Length:	236	Identity:	43/236 - (18%)
Similarity:	73/236 - (30%)	Gaps:	91/236 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ELPTSYRPQPTPKPPLVPLPSP---------------------------CRRRSSSGLKKRVHFA 61
            |.||......|.:||.:|...|                           .|..:.....::...|
Human   154 EAPTPDTQLDTEQPPRLPGSDPPAELHLSLSEQSASESAPEDQPDREEDPRAGAEDPKAEKSPGA 218

  Fly    62 DEQNVGVQVGSP---AHGELL------RGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHR 117
            |.:.:|.:.|||   :.|.|.      .|.::.....|.:..||....|:.||      :.:...
Human   219 DSKGLGCKRGSPKADSPGSLTITPVAPGGGLLGPSHSYSSSPLSLFRLQEQFR------QHMAAT 277

  Fly   118 DNKIAYTQGATQEAGP---GSRSNSTLPPVTPDLMP-------------------HRG--PSPFL 158
            :|.:.|:  :.:..||   .:.:.:.:|.:..::.|                   |:|  .||.|
Human   278 NNLVHYS--SFEVGGPAPAAAAAAAAVPYLGVNMAPLGSLHCQSYYQSLSAAAAAHQGVWGSPLL 340

  Fly   159 PGP-----------------------SHFERALQLPVDTLP 176
            |.|                       ...:.|..|.:||||
Human   341 PAPPAGLAPASATLNSKTTSIENLRLRAKQHAASLGLDTLP 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	12/55 (22%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558
DMBX1	NP_001374705.1	Interaction with OTX2 and is required for repressor activity. /evidence=ECO:0000250\|UniProtKB:Q91ZK4	1..156		1/1 (100%)
		Homeobox	74..128	CDD:395001
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..252		18/97 (19%)
		OAR	357..373	CDD:397759	0/15 (0%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	359..372		0/12 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030