DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and LDB3

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	384	Identity:	81/384 - (21%)
Similarity:	138/384 - (35%)	Gaps:	95/384 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNKIAYTQGATQEAGPGSRSN 138
            |..:|.:||::..|...:...::|.:||...:.|...:.|.:.:..:            |...|
Human    39 AQSQLSQGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKR------------PIPIS- 90

  Fly   139 STLPPVTPDLMPHRGPSPFLPGPSHFERALQLPVDTLPQTVFPQLNSSGGYEVPSTVFSPKPTRD 203
            :|.|||                        |.|:..:|....|.|:::|....|    ||.|
Human    91 TTAPPV------------------------QTPLPVIPHQKDPALDTNGSLVAP----SPSP--- 124

  Fly   204 HQQDVDEEQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYPNPA-VRAHPGHDYHDSIMKQR 267
                   |..|....|  .||.:.|........|:..|.|....:|. .||.         ::.:
Human   125 -------EARASPGTP--GTPELRPTFSPAFSRPSAFSSLAEASDPGPPRAS---------LRAK 171

  Fly   268 VADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIED-------TIRST-----VPFATSESNR 320
            .:......::|.:|..|....:|:|:||||||...:.:       ::|..     :|.......|
Human   172 TSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSLRGKASGVGLPGGADYQER 236

  Fly   321 -----LKDSPL--HRPLPTKLNGYKKTV---QYD-PRNSETYRAIQEEGGYSNYGQSSPQEVTIP 374
                 ||||.|  |:|:..|..|.|.|:   ||: |.:..:..||.:........|.|....::|
Human   237 FNPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLP 301

  Fly   375 VQTKVYQPNRLVPGKKPVSAPVSRPPYNVVNTHDENIRQSGSFNRLMYSVIG---ATEY 430
            ::      :..|....||...|.:......:..||..|:|.:.....:.::.   .||:
Human   302 IK------DLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	10/40 (25%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	27/96 (28%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492	10/41 (24%)
		DUF4045	<77..180	CDD:330572	29/164 (18%)
		ZM	189..214	CDD:128974	8/24 (33%)
		DUF4749	263..353	CDD:318205	17/95 (18%)
		Atrophin-1	<387..554	CDD:331285
		LIM1_ZASP_Cypher	556..607	CDD:188838
		LIM2_Enigma_like	615..666	CDD:188748
		LIM3_Enigma_like	674..727	CDD:188749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	71	1.000	Inparanoid score	I5310
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.180