Protein Alignment Zasp66 and PDLIM5

DIOPT Version :10

• Sequence 1: NP_729395.2
• Gene: Zasp66 / 38988
• FlyBaseID: FBgn0035917
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_001243355.2
• Gene: PDLIM5 / 10611
• HGNCID: 17468
• Length: 625
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 93/478 - (19%)
• Similarity: 152/478 - (31%)
• Gaps: 144/478 - (30%)

  Fly    71 GSPAHGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVVHRDNK--------------I 121
            |..|...:..||::..|...:|:.::|.:||...:|....:.:.:.|.:.              .
Human    37 GKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVT 101

  Fly   122 AYTQGATQEAGPGSR---------SNSTLPPVTP------------------------------- 146
            :.....:||...|.|         .|..:||..|
Human   102 SVCSETSQELAEGQRRGSQGDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSDASKKRLIEDTE 166

  Fly   147 DLMPHRGPSPF--------LPGPSH-------------FERALQ-LPVDTLPQTVFPQLNSSGGY 189
            |..|..|.:..        :.|..|             |:.||: ||.........||:.:.|..
Human   167 DWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKAKFDSALEDLPKSGPHPPATPQVLTIGSQ 231

  Fly   190 -----EVPSTVFSPKPTRDHQQDVDE--EQAAIVNQPYRTTPLVLPGAKVKKDAPTTESYLRHYP 247
                 :|.:|..|...:..:.:|..|  ...:..:.|.|.:..||..|     |.|..:.:.
Human   232 VATLSKVATTYSSLSSSTGNVEDSFEGFRNFSTFSSPARYSAAVLSSA-----AATVSAVIA--- 288

  Fly   248 NPAVRAHPGHDYH---DSIMKQRVADTMLHKVV-GSEADTGRVFHKQFNSPIGLYSNNNIEDT-- 306
             ...|.:....||   |::....|:..:....: .|...||.:..|:        ::|:.|.:
Human   289 -TKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGSIHVKK--------TSNSQEPSPQ 344

  Fly   307 IRSTVPFATSESNRLKDSPLH-RPLPTKLN-----------------GYKKTVQYDP-----RNS 348
            :.|:|....|....| |||.. ||..|.|.                 .:::..|..|     .||
Human   345 LASSVASTRSMPESL-DSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNS 408

  Fly   349 ETYRAIQEEGGYSNYGQSSPQEVTIPVQTKVYQPNRLVPGKK-PVSA---PVSRPPYNVV---NT 406
            .||........ |..||:.|.:    ..|.|.:...:..||: |:.|   .|.|.|:.|.   :.
Human   409 ATYSGSVAPAN-SALGQTQPSD----QDTLVQRAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSW 468

  Fly   407 HDENIRQSGSFNRLMYSVIGATE 429
            |.|....:...|.:.|  ||..|
Human   469 HPEEFNCAHCKNTMAY--IGFVE 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_canonical	<68..117	CDD:483948	10/45 (22%)
		DUF4749	285..374	CDD:464948	24/113 (21%)
PDLIM5	NP_001243355.2	PDZ_PDLIM-like	5..83	CDD:467235	10/45 (22%)
		DUF4749	105..202	CDD:464948	13/96 (14%)
		LIM1_ENH	449..500	CDD:188837	12/43 (28%)
		LIM	508..559	CDD:413332
		LIM3_ENH	567..621	CDD:188843