DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp66 and PATJ

DIOPT Version :9

Sequence 1:	NP_729395.2	Gene:	Zasp66 / 38988	FlyBaseID:	FBgn0035917	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	438	Identity:	88/438 - (20%)
Similarity:	148/438 - (33%)	Gaps:	147/438 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SPA--HGELLRGDIISKIGEYDARDLSHADAQQLFRGAGNEIRLVV--------------HRDNK 120
            |||  ...|..||.|.::...|.::.||::|.:..:.|||.:..:|              ::.||
Human  1111 SPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANK 1175

  Fly   121 IAYTQGA-TQEAGPGSRSNSTLPPVTPDLMPHRGPSPF--------------------------- 157
            |...|.. |||  ...:...|.||      |.:.|.|:
Human  1176 ITGNQNQDTQE--KKEKRQGTAPP------PMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYAD 1232

  Fly   158 LPGPSHF------ERALQLPV----DTLPQTVF-PQLNSSGGYEVPSTVFSPKPTRDHQQDVDEE 211
            |||..|.      :..|.|.:    |....::| ..:|..|    |:..       |.:..:.:|
Human  1233 LPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEG----PAAA-------DGRMRIGDE 1286

  Fly   212 QAAIVNQPYRTTPLVLPG------AKVKKDAPTTES--YLRH---------YPNPAVRAHPGHDY 259
            ...|.||       :|.|      :.:.|.||:...  ::|:         .|.|...:.|
Human  1287 LLEINNQ-------ILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSP---- 1340

  Fly   260 HDSIMKQRVADTMLHKVVGSEADTGRVFHKQFNSPIGLYSNNNIEDTIRSTVPFATSESNRLKDS 324
             .||..|.          |:|             ||....:.::|..|:.   ...|||.:|:|.
Human  1341 -SSIEDQS----------GTE-------------PISSEEDGSVEVGIKQ---LPESESFKLEDM 1378

  Fly   325 PLHRPLPTKLNG------YKKTVQYDPRNSETYRAIQEEGGYSNYGQSSPQEVTIPVQTKVYQPN 383
                   :::.|      .:|.::|.|.|:.:....|:   |......|.||:.:...:..:..:
Human  1379 -------SQVIGQGMVADQQKALEYPPDNAVSQMKQQK---YPTKVSFSSQEIPLAPASSYHSTD 1433

  Fly   384 RLVPGKKPVSAPVSRPPYN--VVNTHDENIRQSGSFNRLMYSVIGATE 429
            ....|.....||:|..|..  :|...:..|..|...:.|..|::|..:
Human  1434 ADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKD 1481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp66	NP_729395.2	PDZ_signaling	<68..115	CDD:238492	14/44 (32%)
Zasp66	NP_729395.2	DUF4749	285..359	CDD:292558	15/79 (19%)
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	246..325	CDD:238492
		PDZ_signaling	366..450	CDD:238492
		PDZ_signaling	570..634	CDD:238492
		PDZ	683..772	CDD:214570
		PDZ_signaling	1066..1157	CDD:238492	14/45 (31%)
		PDZ	1236..1321	CDD:214570	18/102 (18%)
		PDZ	1459..1574	CDD:214570	5/23 (22%)
		PDZ_signaling	1586..1666	CDD:238492
		PDZ_signaling	1729..1814	CDD:238492
		PDZ_signaling	1852..1936	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900