DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	380	Identity:	73/380 - (19%)
Similarity:	137/380 - (36%)	Gaps:	101/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AQKRALY---KQFIEELVLPPGHSSNRASVDGGD-----------GDKVD-----SGGVGLQDHP 110
            |.:|..|   |.|.|...:....|..:...:.||           .||.:     |||     .|
Human   419 ANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGG-----GP 478

  Fly   111 LSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERV--- 172
            :|...:.|...  :||| |.....||.:.||             |.:::|.||...:.|..:
Human   479 MSPQDDEAEEE--SDNE-LSSGTGDVSKDCP-------------EKILYSWGELLGKWHSNLGAR 527

  Fly   173 -----------VPAVL-------------SSANVERKGLGMTK----INLITKRSVENYAAME-- 207
                       ||..|             :.|.::|..:.:||    .::||:.....:.|.:
Human   528 PKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYF 592

  Fly   208 -----EGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFC 267
                 :|||:.:::.:    .|:..:...||.||.:.:...:...|           .|...|..
Human   593 KDTGGDGQESLYKICK----AYSVYDEDIGYCQGQSFLAAVLLLHM-----------PEEQAFCV 642

  Fly   268 FTALMSE--IRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLL 330
            ...:|.:  :||.:....:|..  .||.  :|..:::.:...::.......|....|:.:|...|
Human   643 LVKIMYDYGLRDLYRNNFEDLH--CKFY--QLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTL 703

  Fly   331 LSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDFASNVKLLQ 385
            .:.:|||..|..|.|.:..  :..:.:..:..:::...:|.:|:.||...:|..:
Human   704 FTAKFPLCMVFHIIDLLLC--EGLNIIFHVALALLKTSKEDLLQADFEGALKFFR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	33/194 (17%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:315198	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..503		14/49 (29%)
		RabGAP-TBC	541..744	CDD:306939	37/223 (17%)
		DUF3084	800..>1018	CDD:331293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810