DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and TBC1D10A

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001191169.1	Gene:	TBC1D10A / 83874	HGNCID:	23609	Length:	515	Species:	Homo sapiens

Alignment Length:	343	Identity:	62/343 - (18%)
Similarity:	115/343 - (33%)	Gaps:	113/343 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VP-DVQSFRALSWKLLLGYLGPRRSSWTTTLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDK 98
            || :|...|...|..:|       ::|...:|:|....:...:: .:||       |:.|.....
Human    81 VPLEVLRQRESKWLDML-------NNWDKWMAKKHKKIRLRCQK-GIPP-------SLRGRAWQY 130

  Fly    99 VDSGGVGLQDHP-----LSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVV 158
            :..|.|.||.:|     |...|        .|.::|..|::|:.|            .:|...:.
Human   131 LSGGKVKLQQNPGKFDELDMSP--------GDPKWLDVIERDLHR------------QFPFHEMF 175

  Fly   159 HSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFI 223
            .|:|.||:                                                :.:.|:|..
Human   176 VSRGGHGQ------------------------------------------------QDLFRVLKA 192

  Fly   224 YAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIKTLD--D 285
            |....|.:||.|....|...:...|.::           ..|:|...:..: :..::.:.|:  .
Human   193 YTLYRPEEGYCQAQAPIAAVLLMHMPAE-----------QAFWCLVQICEKYLPGYYSEKLEAIQ 246

  Fly   286 AEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFAD 350
            .:|.|.|.:.:..:.:..|.||      .|::.|..|...|.....|:..|...|||:||..|.:
Human   247 LDGEILFSLLQKVSPVAHKHLS------RQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCE 305

  Fly   351 EQRFDFLIKICCSMILIQ 368
            ..:..|.:    .::|::
Human   306 GVKIIFRV----GLVLLK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	32/181 (18%)
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		TBC	117..320	CDD:214540	53/300 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..515
		ZipA	<403..>502	CDD:331990
		Binding to the PDZ domain of EBP50	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810