DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Tbc1d9b

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001277689.1	Gene:	Tbc1d9b / 76795	MGIID:	1924045	Length:	1263	Species:	Mus musculus

Alignment Length:	283	Identity:	61/283 - (21%)
Similarity:	102/283 - (36%)	Gaps:	93/283 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 YPCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEV 216
            |..|:|..|.|::.           |::..:||.          ..||:..:.|.:  .|.....
Mouse   535 YYAELVEKSLGKYS-----------LATEEIERD----------LHRSMPEHPAFQ--NELGIAA 576

  Fly   217 VQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFI 280
            ::|:|..||..||..||.|.||.:...:         |.|.:..||  |:...||... :.|::.
Mouse   577 LRRVLTAYAFRNPTIGYCQAMNIVTSVL---------LLYGSEEEA--FWLLVALCERMLPDYYN 630

  Fly   281 KTLDDA--EGGI-----KFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRW-LTLLLSQEFPL 337
            ..:..|  :.||     :.::.|||.  |.::|.:...:          |..| |||.|| ..|.
Mouse   631 TRVVGALVDQGIFEELTRDVLPRLSE--KMQELGVISSI----------SLSWFLTLFLS-VMPF 682

  Fly   338 PDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILE-----NDFASNVKLLQNY---------- 387
            ...:.|.|..|.:.      ||:...:.|...:|.:|     ||....:.:|..|
Mouse   683 ESAVVIVDCFFYEG------IKVILQVALAVLDANVEQLLDCNDEGEAMTVLGRYLDNVVNKQSI 741

  Fly   388 ----------------PPIDINV 394
                            ||:::::
Mouse   742 SPPIPHLHALLTSGDDPPVEVDI 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	46/190 (24%)
Tbc1d9b	NP_001277689.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..449
		TBC	506..716	CDD:214540	55/233 (24%)
		EFh	<856..907	CDD:298682
		EFh	887..912	CDD:197492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810