DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Tbc1d2b

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_919315.2	Gene:	Tbc1d2b / 67016	MGIID:	1914266	Length:	965	Species:	Mus musculus

Alignment Length:	246	Identity:	53/246 - (21%)
Similarity:	101/246 - (41%)	Gaps:	55/246 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 HGRRLHERVVP----AVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIY 224
            |.|:..:.:.|    .:|..| :|::.....:|.|...|::.|............:.::.:|..:
Mouse   681 HTRKFKDSMEPDYFQTLLQKA-LEKQNPASKQIELDLLRTLPNNKHYSSPTSEGIQKLRSVLLAF 744

  Fly   225 AKLNPGQGYVQGMNEIVG-PIYYVMASDPDLTYRAHAEADCFFCFTALMSEI--RDFFIKTLDDA 286
            :..||..||.||:|.:|. .:.|:            .:.|.|:|...::...  ||::.|||
Mouse   745 SWRNPDIGYCQGLNRLVAVALLYL------------DQEDAFWCLVTIVEVFMPRDYYTKTL--- 794

  Fly   287 EGGIKFMMARLSNMLKSK-DLSIYELLRSQEL-----HPQYY-------SFRWLTLLLSQEFPLP 338
                          |.|: |..::..|.|::|     |.:.|       :|.|. |::..:..:.
Mouse   795 --------------LGSQVDQRVFRDLLSEKLPRLHTHFEQYKVDYTLITFNWF-LVVFVDSVVS 844

  Fly   339 DVL-RIWDSVFADEQRFDFLIKICCSMILIQREAILE-NDFASNVKLLQNY 387
            |:| :||||...:..:..|  :...::...:.|.||: .|..|..|.|:.:
Mouse   845 DILFKIWDSFLYEGPKVIF--RFALALFKYKEEEILKLQDSMSIFKYLRYF 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	41/198 (21%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		PH_TBC1D2A	36..144	CDD:269966
		PH	38..136	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..340
		HIP1_clath_bdg	<341..>378	CDD:293123
		RabGAP-TBC	710..878	CDD:278964	41/199 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810