DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPsec and TBC1D2

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001254500.1	Gene:	TBC1D2 / 55357	HGNCID:	18026	Length:	928	Species:	Homo sapiens

Alignment Length:	192	Identity:	40/192 - (20%)
Similarity:	75/192 - (39%)	Gaps:	19/192 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 VVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRIL 221
            :||.:.:|   ||.......|.|....|:.....:|.|...|:..|.........:..:.::|:|
Human   638 LVHLRVQH---LHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVL 699

  Fly   222 FIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSEI--RDFFIKTLD 284
            ..::..||..||.||:|.:......|:          ..|...|:|..|::..|  .|::..||.
Human   700 LAFSWQNPTIGYCQGLNRLAAIALLVL----------EEEESAFWCLVAIVETIMPADYYCNTLT 754

  Fly   285 DAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDS 346
            .::...:.    |.::|..|...:...|....:.....:|.|..::.:.......:||:||:
Human   755 ASQVDQRV----LQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDA 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	32/158 (20%)
TBC1D2	NP_001254500.1	Interaction with CADH1	1..169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		PH_TBC1D2A	47..147	CDD:269966
		PH	47..139	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..275
		Interaction with RAC1. /evidence=ECO:0000269\|PubMed:20116244	295..433
		TBC	625..837	CDD:214540	40/192 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810