Protein Alignment GAPsec and TBC1D8B

DIOPT Version :9

• Sequence 1: NP_648245.2
• Gene: GAPsec / 38987
• FlyBaseID: FBgn0035916
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 76/386 - (19%)
• Similarity: 123/386 - (31%)
• Gaps: 129/386 - (33%)

  Fly     8 VKEFEDVLAGPQDLIDLKQLRKLAFN-GVPDVQSFRALSWKLLLGYLGPRRSSWTT--------- 62
            ||:||.::|            ||... |....| :..:|.:|.:       ||.:|
Human   374 VKDFEQLVA------------KLRLRCGAASTQ-YHDISTELAI-------SSESTEPSDNFEVQ 418

  Fly    63 TLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDKVDSGGVGLQDHPLSEG-PESAWNTFFND- 125
            :|..:|...|....|.::...|..|..:               |....|.|. .|.:|...|.:
Human   419 SLTSQRECSKTVNTEALMTVFHPQNLET---------------LNSKMLKEKMKEQSWKILFAEC 468

  Fly   126 ----NEFLLQIDKD-VRRLCPD-------------ISFFQQPTDYPCEIVVHSKGEHGRRLHERV 172
                :.|..:..:| |.|..|:             ::......||..|:|..|.|
Human   469 GRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLG---------- 523

  Fly   173 VPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQGM 237
             ...|::..:||.          .:||:..:.|.:  .:.....::|:|..||..||..||.|.|
Human   524 -TCNLATEEIERD----------LRRSLPEHPAFQ--SDTGISALRRVLTAYAYRNPKIGYCQAM 575

  Fly   238 NEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIKTLDDAEGGIKFMMARLSNML 301
            |.:...:         |.|....||  |:...|:... :.|:|.:.:..|
Human   576 NILTSVL---------LLYAKEEEA--FWLLVAVCERMLPDYFNRRIIGA--------------- 614

  Fly   302 KSKDLSIYELLRSQELHPQY------------YSFRWLTLLLSQEFPLPDVLRIWDSVFAD 350
             ..|.:::|.|....| ||.            .|..|...|.....|:...:.:.|..|.|
Human   615 -LVDQAVFEELIRDHL-PQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYD 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	36/173 (21%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	7/25 (28%)
		TBC	486..694	CDD:214540	47/239 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810