DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and TBC1D13

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_060671.3	Gene:	TBC1D13 / 54662	HGNCID:	25571	Length:	400	Species:	Homo sapiens

Alignment Length:	405	Identity:	209/405 - (51%)
Similarity:	281/405 - (69%)	Gaps:	15/405 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SIFKARVKEFEDVLAGPQDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSWTTTLAQ 66
            |:.|:|:.:|:|||..|.  |.|::||:|:|:|:|.....|.|.||:||.||...|:|||:.||:
Human     3 SLHKSRIADFQDVLKEPS--IALEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWTSILAK 65

  Fly    67 KRALYKQFIEELVLPPGHSSNRASVDGGDGDKVDSGGVGLQDHPLSEGPESAWNTFFNDNEFLLQ 131
            :|.||.||:.|:::.||.:.....|...|        |..:||||:..|:|.|||:|.|||.|||
Human    66 QRELYAQFLREMIIQPGIAKANMGVSRED--------VTFEDHPLNPNPDSRWNTYFKDNEVLLQ 122

  Fly   132 IDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLIT 196
            ||||||||||||||||:.|||||.:::..:.|. ..|.:||....|.|..|.|...|:|.::...
Human   123 IDKDVRRLCPDISFFQRATDYPCLLILDPQNEF-ETLRKRVEQTTLKSQTVARNRSGVTNMSSPH 186

  Fly   197 KRSV----ENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYR 257
            |.||    ..|..:..|.|||||||:||||||||||||..|||||||||||:||..|:||:..::
Human   187 KNSVPSSLNEYEVLPNGCEAHWEVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWK 251

  Fly   258 AHAEADCFFCFTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYY 322
            .|||||.|||||.||:||||.|||:|||::.||.:.|.::.:.||.||:.:|..|:.|.:.||::
Human   252 EHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIKPQFF 316

  Fly   323 SFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDFASNVKLLQNY 387
            :||||||||||||.||||:|||||:|||:.|||||:.:||:|:::.||.:||.||..|::|||:|
Human   317 AFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNMRLLQDY 381

  Fly   388 PPIDINVVIAHAGSL 402
            |..|:..::..|..|
Human   382 PITDVCQILQKAKEL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	108/185 (58%)
TBC1D13	NP_060671.3	TBC	32..367	CDD:214540	182/343 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	220	1.000	Domainoid score	I2639
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10068
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1802
Isobase	1	0.950	-	0	Normalized mean entropy	S2189
OMA	1	1.010	-	-		QHG54276
OrthoDB	1	1.010	-	-		D350831at33208
OrthoFinder	1	1.000	-	-		FOG0001234
OrthoInspector	1	1.000	-	-		oto90861
orthoMCL	1	0.900	-	-		OOG6_102218
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1952
SonicParanoid	1	1.000	-	-		X4286
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820