DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Tbc1d8

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_017177250.1	Gene:	Tbc1d8 / 54610	MGIID:	1927225	Length:	1160	Species:	Mus musculus

Alignment Length:	277	Identity:	60/277 - (21%)
Similarity:	98/277 - (35%)	Gaps:	85/277 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SEGPE----------SAWNTFFND---NEFLLQIDKDVRRL----CPD-------ISFFQQPTDY 152
            |:.|:          |.||..|.:   ...:.:.:| :|:|    .|:       :.|....||
Mouse   476 SQSPDSRLSREQIKISLWNDHFVEYGRTVCMFRTEK-IRKLVAMGIPESLRGRLWLLFSDAVTD- 538

  Fly   153 PCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVV 217
                :....|.:|..:.:.:....|.:..:||.          ..||:..:.|.:  .|.....:
Mouse   539 ----LASHPGYYGNLVEQSLGRCCLVTEEIERD----------LHRSLPEHPAFQ--NETGIAAL 587

  Fly   218 QRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIK 281
            :|:|..||..||..||.|.||.:...:         |.|....||  |:...|:... :.|:|..
Mouse   588 RRVLTAYAHRNPKIGYCQSMNILTSVL---------LLYAKEEEA--FWLLVAVCERMLPDYFNH 641

  Fly   282 TLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQY------------YSFRW-LTLLLSQ 333
            .:..|:                .|.|::|.|..::| |:.            .|..| |||.||
Mouse   642 RVIGAQ----------------VDQSVFEELIKEQL-PELAEHMSDLSALASISLSWFLTLFLS- 688

  Fly   334 EFPLPDVLRIWDSVFAD 350
            ..||...:.:.|..|.|
Mouse   689 IMPLESAVHVVDCFFYD 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	42/174 (24%)
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	519..725	CDD:214540	51/233 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810