DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006238118.1	Gene:	Tbc1d2 / 313234	RGDID:	1306860	Length:	924	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	75/408 - (18%)
Similarity:	126/408 - (30%)	Gaps:	157/408 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SIFKARVKEFED--VLAGPQ-DLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSWTT- 62
            |:..:.|.|::|  .|..|. ::.|||.|.|:.   ..:|:|...|:   |.....|.|..|.|
  Rat   547 SVGLSPVSEYDDYGFLTVPDYEVEDLKLLAKIQ---ALEVRSHHLLA---LEAVERPLRDRWATL 605

  Fly    63 TLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDKV------------DSGGVGLQ-------- 107
            |.....|..||.:            ||.|......:|            .|.|...:
  Rat   606 TELMPSAELKQLL------------RAGVPREHRPRVWRWLVHRRVQHLHSSGCYQELLARGRAC 658

  Fly   108 DHPLSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPT-DYPCEIVVHSKGEHGRRLHER 171
            :||.:.                 ||:.|:.|..|....|..|| .:|
  Rat   659 EHPAAR-----------------QIELDLNRTFPTNKHFTCPTSSFP------------------ 688

  Fly   172 VVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQG 236
                                                       :.::|:|..::..||..||.||
  Rat   689 -------------------------------------------DKLRRVLLAFSWQNPTIGYCQG 710

  Fly   237 MNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSEI--RDFFIKTLDDAEGGIKFMMARLSN 299
            :|.:......|:..          |...|:|..|::..|  .:::.|||..::...:.:...||.
  Rat   711 LNRLAAIALLVLED----------EESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSE 765

  Fly   300 ML---------KSKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFD 355
            .|         :..|||:             .:|.|..::.:.......:||:||:...:..:..
  Rat   766 KLPRLTAHLGQRHVDLSL-------------ITFNWFLVIFADSLISDILLRVWDAFLYEGTKVV 817

  Fly   356 FLIKICCSMILIQREAIL 373
            |  :...::.....||||
  Rat   818 F--RYALAIFKYNEEAIL 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	33/192 (17%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966
		PH	44..137	CDD:278594
		TBC	621..833	CDD:214540	48/314 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810