DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPsec and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006250167.1	Gene:	Rabgap1l / 304914	RGDID:	1304620	Length:	1051	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	73/378 - (19%)
Similarity:	135/378 - (35%)	Gaps:	97/378 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AQKRALY---KQFIEELVLPPGHSSNRASVDGGD-----------GDKVD-----SGGVGLQDHP 110
            |.:|..|   |.|.|...:....|..:.....||           .||.:     |||     .|
  Rat   419 ANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPVTPTSGG-----GP 478

  Fly   111 LSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERV--- 172
            .|...:.|...  :||| |.....||.:.||             |.:::|.||...|.|..:
  Rat   479 ASPQEDEAEEE--SDNE-LSSGTGDVSKDCP-------------EKILYSWGELLGRWHNNLNAR 527

  Fly   173 -----------VPAVL-------------SSANVERKGLGMTK----INLITKRSVENYAAME-- 207
                       ||..|             :.|.:::..:.:||    .::||:.....:.|.:
  Rat   528 PKGLPTLVKSGVPEALRAEVWQLLAGCHDNQAMLDKYRILITKDSAQESVITRDIHRTFPAHDYF 592

  Fly   208 -----EGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFC 267
                 :|||:.:::.:    .|:..:...||.||.:.:...:         |.:....:|.|...
  Rat   593 KDTGGDGQESLYKICK----AYSVYDEDIGYCQGQSFLAAVL---------LLHMPEEQAFCVLV 644

  Fly   268 FTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLLLS 332
            ......::||.:....:|..  .||.  :|..:::.:...:|.......|....|:.:|...|.:
  Rat   645 NIMYKYKLRDLYKNNFEDLH--CKFY--QLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFT 705

  Fly   333 QEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDFASNVKLLQ 385
            .:|||..|..|.|.:..  :..:.:..:..:::...:|.:|:.||...:|..:
  Rat   706 AKFPLCMVFHIIDLLLC--EGLNIIFHVALALLKTSKEDLLQADFEGALKFFR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	33/192 (17%)
Rabgap1l	XP_006250167.1	PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	340..421	CDD:289256	1/1 (100%)
		RabGAP-TBC	541..744	CDD:278964	36/221 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810