DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006496938.1	Gene:	Rabgap1l / 29809	MGIID:	1352507	Length:	1051	Species:	Mus musculus

Alignment Length:	380	Identity:	74/380 - (19%)
Similarity:	135/380 - (35%)	Gaps:	101/380 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AQKRALY---KQFIEELVLPPGHSSNRASVDGGD-----------GDK------VDSGGVGLQDH 109
            |.:|..|   |.|.|...:....|..:.....||           .||      ..:||
Mouse   419 ANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEVVSLQRESDKEEPITPTSAGG------ 477

  Fly   110 PLSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERV-- 172
            |:|...:.|...  :||| |.....||.:.||             |.:::|.||...|.|..:
Mouse   478 PMSPQEDEAEEE--SDNE-LSSGTGDVSKDCP-------------EKILYSWGELLGRWHNNLGG 526

  Fly   173 ------------VP--------AVLSSANVERKGLGMTKINLITKRSVE----------NYAAME 207
                        ||        .:|:..:..::.|...:| ||||.|.:          .:.|.:
Mouse   527 RPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDKYRI-LITKDSAQESVITRDIHRTFPAHD 590

  Fly   208 -------EGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCF 265
                   :|||:.:::.:    .|:..:...||.||.:.:...:         |.:....:|.|.
Mouse   591 YFKDTGGDGQESLYKICK----AYSVFDEDIGYCQGQSFLAAVL---------LLHMPEEQAFCV 642

  Fly   266 FCFTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLL 330
            ........::||.:....:|..  .||.  :|..:::.:...:|.......|....|:.:|...|
Mouse   643 LVTIMYGYKLRDLYRNNFEDLH--CKFY--QLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTL 703

  Fly   331 LSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDFASNVKLLQ 385
            .:.:|||..|..|.|.:..  :..:.:..:..:::...:|.:|:.||...:|..:
Mouse   704 FTAKFPLCMVFHIIDLLLC--EGLNIIFHVALALLKTSKEDLLQADFEGALKFFR 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	36/198 (18%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:372133	1/1 (100%)
		RabGAP-TBC	541..744	CDD:366170	38/222 (17%)
		Smc	<814..>1019	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900