DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and TBC1D10B

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_056342.3	Gene:	TBC1D10B / 26000	HGNCID:	24510	Length:	808	Species:	Homo sapiens

Alignment Length:	370	Identity:	65/370 - (17%)
Similarity:	110/370 - (29%)	Gaps:	157/370 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GVPDVQSFRALSWKLLLGYLGPRRSSWTTTLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDK 98
            |:|  .|.||.:|:.|        |:....|.|....:    |||...||
Human   360 GIP--SSLRAKAWQYL--------SNSKELLEQNPGKF----EELERAPG--------------- 395

  Fly    99 VDSGGVGLQDHPLSEGPESAWNTFFNDNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGE 163
                                      |.::|..|:||:.|            .:|...:..::|.
Human   396 --------------------------DPKWLDVIEKDLHR------------QFPFHEMFAARGG 422

  Fly   164 HGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIYAKLN 228
            ||:                                                :.:.|||..|....
Human   423 HGQ------------------------------------------------QDLYRILKAYTIYR 439

  Fly   229 PGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIKTLD--DAEGGI 290
            |.:||.|....:...:...|.::           ..|:|...:..: :..::...|:  ..:|.|
Human   440 PDEGYCQAQAPVAAVLLMHMPAE-----------QAFWCLVQICDKYLPGYYSAGLEAIQLDGEI 493

  Fly   291 KFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFD 355
            .|.:.|.::.|..:.      ||.|.:.|..|...|...:.::..|...|||:||..|.:.
Human   494 FFALLRRASPLAHRH------LRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEG---- 548

  Fly   356 FLIKICCSMILIQREAILENDFASNVKL------------LQNYP 388
              :||...:.|:    :|.:...|..||            |:|.|
Human   549 --VKIIFRVALV----LLRHTLGSVEKLRSCQGMYETMEQLRNLP 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	33/184 (18%)
TBC1D10B	NP_056342.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264
		TBC	357..562	CDD:214540	59/343 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810