DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Tbc1d8b

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001074968.1	Gene:	Tbc1d8b / 245638	MGIID:	1918101	Length:	1114	Species:	Mus musculus

Alignment Length:	373	Identity:	72/373 - (19%)
Similarity:	130/373 - (34%)	Gaps:	100/373 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ARVKEFEDVLAGPQDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSWTTTLAQKRAL 70
            :.:|:||.::|       ..:|:..|.:...||.:..|:|    ....||..:.....|...:..
Mouse   372 SELKDFEQLVA-------KLRLKCRAASTQDDVSTEVAVS----SDSTGPSENFEEQPLTCPKEC 425

  Fly    71 YKQFIEELVLPPGHSSNRASVDGGDGDKVDSGGVGLQDHPLSEG-PESAWNTFFND-----NEFL 129
            .|....|.::...|..|..::|               ...|.|. .|.:||..|::     :.|.
Mouse   426 SKTVNTEALMTVFHPQNLENLD---------------SKMLKEKMKEQSWNILFSECGRGVSMFR 475

  Fly   130 LQIDKD-VRRLCPD-------------ISFFQQPTDYPCEIVVHSKGEHGRRLHERVVPAVLSSA 180
            .:..:| |.|..|:             ::.......|..|:|..|.|...           |::.
Mouse   476 TKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPGYYAEVVEQSLGTSN-----------LATE 529

  Fly   181 NVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIY 245
            .:||.          .:||:..:.|.:  .:.....::|:|..||..||..||.|.||.:...:
Mouse   530 EIERD----------LRRSLPEHPAFQ--SDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVL- 581

  Fly   246 YVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIKTL-----DDA--EGGIKFMMARLSNMLK 302
                    |.|....||  |:...|:... :.|:|.:.:     |.|  |..|:..:.:|::.:
Mouse   582 --------LLYAKEEEA--FWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTDHM- 635

  Fly   303 SKDLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFAD 350
             .|::.:..:          |..|...|.....|:...:.:.|..|.|
Mouse   636 -TDMTFFSSV----------SLSWFLTLFISVLPIESAVNVVDCFFYD 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	35/168 (21%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..420		4/24 (17%)
		TBC	485..693	CDD:214540	45/234 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810