DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and TBC1D30

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_024304669.1	Gene:	TBC1D30 / 23329	HGNCID:	29164	Length:	944	Species:	Homo sapiens

Alignment Length:	242	Identity:	54/242 - (22%)
Similarity:	97/242 - (40%)	Gaps:	54/242 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 ANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWE--VVQRILFIYAKLNPGQGYVQGMNEIVG 242
            :|.:...:|:..:..:.:....:|.    ||||..:  |::|:|..||:.|...||.||.|.:..
Human   286 SNPDDDSMGIQIVKDLHRTGCSSYC----GQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAA 346

  Fly   243 PIYYVMASDPDLTYRAHAEADCFFCFTALMSEI--RDFFIKTLDDAEGGIKFMMARLSNMLK--- 302
            .|..||..:         |.|.......|:.::  ..:|:..|    ..:...||...::|:
Human   347 LILEVMEGN---------EGDALKIMIYLIDKVLPESYFVNNL----RALSVDMAVFRDLLRMKL 398

  Fly   303 ---SKDLSIYELLRSQELHPQY-------YSFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFDFL 357
               |:.|...:...::|....|       ::.:|...|.:...|...||:||||||.:.......
Human   399 PELSQHLDTLQRTANKESGGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILR 463

  Fly   358 IKI-----------CC--------SMILIQREAILENDFASNVKLLQ 385
            :.:           ||        :|..:.:| :||||...:.:|:|
Human   464 VSLAIWAKLGEQIECCETADEFYSTMGRLTQE-MLENDLLQSHELMQ 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	46/217 (21%)
TBC1D30	XP_024304669.1	RabGAP-TBC	296..476	CDD:306939	42/196 (21%)
TBC1D30	XP_024304669.1	DUF4682	637..785	CDD:318030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900