DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GAPsec and TBC1D2B

DIOPT Version :9

Sequence 1:NP_648245.2 Gene:GAPsec / 38987 FlyBaseID:FBgn0035916 Length:403 Species:Drosophila melanogaster
Sequence 2:NP_001374071.1 Gene:TBC1D2B / 23102 HGNCID:29183 Length:974 Species:Homo sapiens


Alignment Length:451 Identity:84/451 - (18%)
Similarity:163/451 - (36%) Gaps:146/451 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 QDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSWTTTLAQKRALYKQFIEELVLPPG 83
            :::::|..||:.|.....|:.:               :.||....|.|..:.|...::|:..|. 
Human   505 KEILELSALRRNAERRERDLMA---------------KYSSLEAKLCQIESKYLILLQEMKTPV- 553

  Fly    84 HSSNRASVDGGDGDKV------DSGGVGLQDHP-------------------------------- 110
                 .|.|.|...:|      |:..|..|:.|                                
Human   554 -----CSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVA 613

  Fly   111 -----------LSEGPESA----WNTFFNDNEFLLQIDKDVRRLC-PDISFFQQ---PTDYPCEI 156
                       |:|..|.:    |     :|.|...:::::  :| |::....:   |.::..::
Human   614 KVRALDLKTLYLTENQEVSTGVKW-----ENYFASTVNREM--MCSPELKNLIRAGIPHEHRSKV 671

  Fly   157 VVHSKGEHGRRLHERVVPA---VLSSANVERKGLGMTKINLITKRSVEN---YAA-MEEGQEAHW 214
            .......|.|:..:...|.   .|....:|::.....:|.|...|::.|   |:. ..||.:.  
Human   672 WKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQK-- 734

  Fly   215 EVVQRILFIYAKLNPGQGYVQGMNEIVG-PIYYVMASDPDLTYRAHAEADCFFCFTALMSEI--R 276
              ::.:|..::..||..||.||:|.:|. .:.|:            .:.|.|:|...::...  |
Human   735 --LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYL------------EQEDAFWCLVTIVEVFMPR 785

  Fly   277 DFFIKTLDDAEGGIKFMMARLSNMLKSK-DLSIYELLRSQEL-----HPQYY-------SFRWLT 328
            |::.|||                 |.|: |..::..|.|::|     |.:.|       :|.|. 
Human   786 DYYTKTL-----------------LGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWF- 832

  Fly   329 LLLSQEFPLPDVL-RIWDSVFADEQRFDFLIKICCSMILIQREAILE-NDFASNVKLLQNY 387
            |::..:..:.|:| :||||...:..:..|  :...::...:.|.||: .|..|..|.|:.:
Human   833 LVVFVDSVVSDILFKIWDSFLYEGPKVIF--RFALALFKYKEEEILKLQDSMSIFKYLRYF 891

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAPsecNP_648245.2 TBC <191..373 CDD:214540 44/202 (22%)
TBC1D2BNP_001374071.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
PH_TBC1D2A 36..144 CDD:269966
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 272..348
Smc <338..552 CDD:224117 11/61 (18%)
RabGAP-TBC 665..876 CDD:366170 49/246 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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