DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and Rabgap1

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001349885.1	Gene:	Rabgap1 / 227800	MGIID:	2385139	Length:	1064	Species:	Mus musculus

Alignment Length:	211	Identity:	38/211 - (18%)
Similarity:	78/211 - (36%)	Gaps:	40/211 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 LITKRSVENYAAME-----------------EGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIV 241
            ||||.|.::.|...                 :||::.:::.:    .|:..:...||.||.:.:.
Mouse   590 LITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICK----AYSVYDEEIGYCQGQSFLA 650

  Fly   242 GPIYYVMASDPDLTYRAHAEADCFFCFTALMSE--IRDFFIKTLDDAEGGIKFMMARLSNMLKSK 304
            ..:...|           .|...|.....:|.:  :|:.|.:..:|..  .||.  :|..:::..
Mouse   651 AVLLLHM-----------PEEQAFSVLVKIMFDYGLRELFKQNFEDLH--CKFY--QLERLMQEY 700

  Fly   305 DLSIYELLRSQELHPQYYSFRWLTLLLSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQR 369
            ...:|.......|....|:.:|...|.:.:|||..|..|.|.:..  :....:..:...::...:
Mouse   701 IPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLC--EGISVIFNVALGLLKTSK 763

  Fly   370 EAILENDFASNVKLLQ 385
            :.:|..||...:|..:
Mouse   764 DDLLLTDFEGALKFFR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	34/197 (17%)
Rabgap1	NP_001349885.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		PTB_Rab6GAP	140..268	CDD:269922
		DUF3694	302..432	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..520
		TBC	558..767	CDD:214540	34/197 (17%)
		ERM	789..1013	CDD:330563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900