DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPsec and tbc-14

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001317776.1	Gene:	tbc-14 / 174986	WormBaseID:	WBGene00008444	Length:	630	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	78/373 - (20%)
Similarity:	129/373 - (34%)	Gaps:	130/373 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPQDLIDLKQLRKLAFNGVPDVQSFRALSWKLLLGYLGPRRSSW---TTTLAQKRA-LYKQFIEE 77
            |..|.:.|..|:...|.|..:.: .|..:||.||||     ..|   .|....:|| |.||:
Worm   305 GSYDPMKLHHLKMNVFRGGLNAE-LRKEAWKCLLGY-----RQWHESDTDFQTRRAELAKQY--- 360

  Fly    78 LVLPPGHSSNRASVDGGDGDKVDSGGVGLQDHPLSEGPESAWNTFFNDNE-----FLLQ---IDK 134
                                               |..:..|.:...|.|     |:.:   ::|
Worm   361 -----------------------------------ENMKKQWMSVTEDQEKRFTKFVKRKSLVEK 390

  Fly   135 DVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRS 199
            ||.|....:.|||                                        |...:||:
Worm   391 DVARTDRTVPFFQ----------------------------------------GDDNVNLV---- 411

  Fly   200 VENYAAMEEGQEAHWEVVQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADC 264
                         |   :..:|..|...|...||||||::...|:.:||..          |.|.
Worm   412 -------------H---LHNVLMTYVMYNFDLGYVQGMSDFASPLLFVMKD----------EVDT 450

  Fly   265 FFCFTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQYYSFRWLTL 329
            |:||..||    :...|..:..:..||..|.:|.:::...:..:...|.|::....|:.|||:.:
Worm   451 FWCFVGLM----ELTQKNFETDQAFIKLQMNQLRDLVMIINPKLANYLESEKSDDMYFCFRWVLV 511

  Fly   330 LLSQEFPLPDVLRIWDSVFADEQRFDFLIKICCSMILIQREAILENDF 377
            ...:||...|..::|:.:::.:....||:.||.:::..|...|::|.|
Worm   512 WFKREFSFLDTCKLWEVLWSGQPCPRFLLLICVAILDSQTNIIIDNQF 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	42/181 (23%)
tbc-14	NP_001317776.1	DUF3548	51..197	CDD:371881
tbc-14	NP_001317776.1	TBC	320..555	CDD:214540	71/352 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810