DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and SGSM1

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001035037.1	Gene:	SGSM1 / 129049	HGNCID:	29410	Length:	1148	Species:	Homo sapiens

Alignment Length:	352	Identity:	80/352 - (22%)
Similarity:	142/352 - (40%)	Gaps:	64/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GYLGPRRSSWTTTLAQKRALYKQFIEELVLPPGHSSNRASVDGGDGDKVDSGGVGL----QDHPL 111
            |.:..|:||..|| :|..|..    |||.:.....|:..:.:..|.....:|.:.:    :|..:
Human   809 GSVDDRQSSEATT-SQDEAPR----EELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVV 868

  Fly   112 SEGPESAWNTFFN------DNEFLLQIDKDVRRLCPDISFFQQPTDYPCEIVVHSKGEHGRRLHE 170
            .||    |.:...      |:|..|..:.::..|.|.::..         .|..|..|
Human   869 MEG----WRSSETEKHGQADSEDNLSEEPEMESLFPALASL---------AVTTSANE------- 913

  Fly   171 RVVPAVLSSANVERKGLGMTKINL--ITK---RSVENYAAMEEGQEAHWEVVQRILFIYAKLNPG 230
             |.|...|......:.|.:..:||  |.|   |...||...   ..|:.|.::.|:..|...:..
Human   914 -VSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYF---TPANLEKLRNIMCSYIWQHIE 974

  Fly   231 QGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSEIRDFFIKTLDDAEGGIKFMMA 295
            .||||||.:::.|:..::..          ||..|.|||.||..:...|     ...|.:....|
Human   975 IGYVQGMCDLLAPLLVILDD----------EALAFSCFTELMKRMNQNF-----PHGGAMDTHFA 1024

  Fly   296 RLSNMLKSKDLSIYELLRSQELHPQ-YYSFRWLTLLLSQEFPLPDVLRIWDSVFADE--QRFDFL 357
            .:.::::..|..::||:.....:.. |:.:||..|...:|....||..:|::::|.:  ....::
Human  1025 NMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYV 1089

  Fly   358 IKICCSMILIQREAILEN--DFASNVK 382
            :.|..:::.:.|:.||||  ||...:|
Human  1090 LFIALALVEVYRDIILENNMDFTDIIK 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	43/189 (23%)
SGSM1	NP_001035037.1	RUN	44..188	CDD:280855
		PH_RUTBC	254..425	CDD:275431
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250\|UniProtKB:Q8BPQ7	256..297
		Required for interaction with RAP family members	301..350
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..411
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..830		8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..894		5/26 (19%)
		TBC	<936..1105	CDD:214540	42/186 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810