DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GAPsec and TBC1D8

DIOPT Version :9

Sequence 1:	NP_648245.2	Gene:	GAPsec / 38987	FlyBaseID:	FBgn0035916	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_005263919.1	Gene:	TBC1D8 / 11138	HGNCID:	17791	Length:	1162	Species:	Homo sapiens

Alignment Length:	352	Identity:	75/352 - (21%)
Similarity:	122/352 - (34%)	Gaps:	116/352 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 SEGPE----------SAWNTFFND---NEFLLQIDKDVRRL----CPD-------ISFFQQPTDY 152
            |:.|:          |.||..|.:   ...:.:.:| :|:|    .|:       :.|....||
Human   484 SQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEK-IRKLVAMGIPESLRGRLWLLFSDAVTD- 546

  Fly   153 PCEIVVHSKGEHGRRLHERVVPAVLSSANVERKGLGMTKINLITKRSVENYAAMEEGQEAHWEVV 217
                :....|.:|..:.|.:....|.:..:||.          ..||:..:.|.:  .|.....:
Human   547 ----LASHPGYYGNLVEESLGKCCLVTEEIERD----------LHRSLPEHPAFQ--NETGIAAL 595

  Fly   218 QRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASDPDLTYRAHAEADCFFCFTALMSE-IRDFFIK 281
            :|:|..||..||..||.|.||.:...:         |.|....||  |:...|:... :.|:|..
Human   596 RRVLTAYAHRNPKIGYCQSMNILTSVL---------LLYTKEEEA--FWLLVAVCERMLPDYFNH 649

  Fly   282 TLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELHPQY------------YSFRW-LTLLLSQ 333
            .:..|:                .|.|::|.|....| |:.            .|..| |||.||
Human   650 RVIGAQ----------------VDQSVFEELIKGHL-PELAEHMNDLSALASVSLSWFLTLFLS- 696

  Fly   334 EFPLPDVLRIWDSVFADEQRFDFLI----------KICCS-------MILIQREAILEND----- 376
            ..||...:.:.|..|.|..:..|.:          .:|.|       |||.:....::|:
Human   697 IMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGP 761

  Fly   377 -------FASNVKLLQNYPPIDINVVI 396
                   |.|:.:  :.||..||:.:|
Human   762 PVGSHHAFFSDDQ--EPYPVTDISDLI 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPsec	NP_648245.2	TBC	<191..373	CDD:214540	48/212 (23%)
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156
		PH-GRAM2_TBC1D8	318..413	CDD:270160
		TBC	527..733	CDD:214540	53/251 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810