DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap1 and LAP3

DIOPT Version :9

Sequence 1:	NP_648244.1	Gene:	S-Lap1 / 38986	FlyBaseID:	FBgn0035915	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_056991.2	Gene:	LAP3 / 51056	HGNCID:	18449	Length:	519	Species:	Homo sapiens

Alignment Length:	531	Identity:	226/531 - (42%)
Similarity:	319/531 - (60%)	Gaps:	34/531 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPVCRRYVPKFIKRSYASQAVNQMLLLQQMDICADQPSRALVIGVYADEEDKNDAGILTPAGWR 79
            |..|.|..|.:|..||.::               ||. ::.||:|:|:.|:: :|....|.||..
Human    11 RVVVRRLAVRRFGSRSLST---------------ADM-TKGLVLGIYSKEKE-DDVPQFTSAGEN 58

  Fly    80 YNLQKTNGRLIEVLRMSGPMPKRGEARLLFAVEPERIPYYSVVAVVGLGKECLGYNPYEVLDEQK 144
            :: :...|:|.|.|.:|||..|.|:.|..:.:..:    :..|.:|||||:..|.:..|...|.|
Human    59 FD-KLLAGKLRETLNISGPPLKAGKTRTFYGLHQD----FPSVVLVGLGKKAAGIDEQENWHEGK 118

  Fly   145 EAIRRSVAAACRILAELDTDRIEVENCGHAESAAEGAALGIWLYQELRDPKTRIFVPAIDLYATK 209
            |.||.:|||.||.:.:|:...:||:.||.|::|||||.||::.|.:|:. |.::.|.| .||.:.
Human   119 ENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQ-KKKMAVSA-KLYGSG 181

  Fly   210 DEVCDIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPTAFAQNVVEVLCKSG---VNVEVKVEGWAE 271
            |:    |.|:.|:..|:.|||.|||.|.|:|.:|||.||: ::|...||.   ..|.::.:.|.|
Human   182 DQ----EAWQKGVLFASGQNLARQLMETPANEMTPTRFAE-IIEKNLKSASSKTEVHIRPKSWIE 241

  Fly   272 SQSMHAFLAVGKASCEPPIFLELSYYGT-CAEERPIVLVGQGITYDAGGLCLKKKKELFNMRGDM 335
            .|:|.:||:|.|.|.|||:|||:.|.|: .|.|.|:|.||:|||:|:||:.:|....:..||.||
Human   242 EQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADM 306

  Fly   336 TGAAVVVATCRAVAGLRLPVNIRGLIPLCENVVGCNSFRPGDMVKSMNGKTIEVQCTDHEDVLVL 400
            .|||.:.:...:.|.|.||:||.||.|||||:....:.:|||:|::.|||||:|..||.|..|:|
Human   307 GGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLIL 371

  Fly   401 ADALLYAQNFCPKCIIDIGTCSGYMRQSLDEAACGVFTNSEILWQQIKHASMHTGDRVWRFPLWN 465
            ||||.||..|.||.|::..|.:|.|..:|...|.||||||..||.::..||:.|||||||.||:.
Human   372 ADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFE 436

  Fly   466 FYSKAVRAGGRSDVQNYGIGRGGRPCKAAAFLREFVPCGQWMHIDATNVMVTNGIDFEYLRRGMA 530
            .|::.|.....:||.|.|..|....|.|||||:|||...:|.|:|...|| ||..:..|||:||.
Human   437 HYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVM-TNKDEVPYLRKGMT 500

  Fly   531 GRPTRTLIEFI 541
            ||||||||||:
Human   501 GRPTRTLIEFL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap1	NP_648244.1	PRK00913	44..542	CDD:234863	219/502 (44%)
S-Lap1	NP_648244.1	Peptidase_M17	55..541	CDD:238247	216/489 (44%)
LAP3	NP_056991.2	Peptidase_M17	33..511	CDD:238247	216/491 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160077
Domainoid	1	1.000	283	1.000	Domainoid score	I1650
eggNOG	1	0.900	-	-		E1_COG0260
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2045
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm41499
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	O	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760