DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment S-Lap1 and loopin-1

DIOPT Version :9

Sequence 1:	NP_648244.1	Gene:	S-Lap1 / 38986	FlyBaseID:	FBgn0035915	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001097338.1	Gene:	loopin-1 / 36847	FlyBaseID:	FBgn0259795	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	202/531 - (38%)
Similarity:	290/531 - (54%)	Gaps:	40/531 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VPKFIKRSYASQAVNQMLLLQQMDICADQPSRALVIGVYADEEDKNDAGILTPAGWRYNL----Q 83
            :|.:  |.||:..               :..:.:|:|||..:.||       |:....|.    .
  Fly    27 IPSY--RRYATSC---------------KSPKGVVVGVYTKDGDK-------PSKTTANAVTLDD 67

  Fly    84 KTNGRLIEVLRMSGPMPKRGEARLLFAVEPERIPYYSVVAVVGLGKECLGYNPYEVLDEQKEAIR 148
            ...|:|:.::|..|.....|:..|....|.|    |..|||||:||:...||..|.|||..|.:|
  Fly    68 ALGGKLLTLIRERGMDGTPGKGLLFSGFEGE----YQAVAVVGVGKQGAAYNENEELDEGMENVR 128

  Fly   149 RSVAAACRILAELDTDRIEVENCGHAESAAEGAALGIWLYQELRDPKTRIFVPAIDLYATKDEVC 213
            .:.....|.|.......:.|::..:.|.|||||||.:|.|...:..|.||..|.:|:|...|.
  Fly   129 VAAGTGARALQLQGMYEVHVDSMDYPEQAAEGAALAVWRYNANKRKKNRIQTPKLDMYGKGDR-- 191

  Fly   214 DIEGWRIGLQKAAAQNLTRQLQEMPSNLLTPTAFAQNVVEVLCKSGVNVEVKVEGWAESQSMHAF 278
              :.|..||.||.:|||.|:|.:.|:|::||:.|||..|:.||..||:|||:...|.|..::::|
  Fly   192 --DAWVRGLFKAESQNLARRLSDTPANMMTPSIFAQAAVDALCPCGVSVEVRSMDWIEDMNLNSF 254

  Fly   279 LAVGKASCEPPIFLELSYYGTCAEERPIVLVGQGITYDAGGLCLKKKKELFNMRGDMTGAAVVVA 343
            |.:.|.|||||:.||.||.||..|:||::|:|||:|:.:||||||.|..:...||.|.||||.|.
  Fly   255 LMIAKGSCEPPLLLECSYCGTTPEDRPVLLLGQGLTFHSGGLCLKPKTGMDQYRGAMAGAAVCVG 319

  Fly   344 TCRAVAGLRLPVNIRGLIPLCENVVGCNSFRPGDMVKSMNGKTIEVQCTDHEDVLVLADALLYAQ 408
            ..||.|.|.||:||..::||||::....:.:.||:|..:||.|:.::..|...|:.|||.|||||
  Fly   320 VLRAAAALSLPLNITAVMPLCEHMPSGMAVKCGDVVTLLNGTTMGIKNVDKAPVVQLADPLLYAQ 384

  Fly   409 -NFCPKCIIDIGTCSGYMRQSLDEAACGVFTNSEILWQQIKHASMHTGDRVWRFPLWNFYSKAVR 472
             .:.||.:|||||.:..:..::...|.|::|.|:.:||..:.:...||||||||||:.:|.:.|.
  Fly   385 ATYKPKLVIDIGTVAMGVNYAVGGGASGLWTTSKSVWQNFRKSGGLTGDRVWRFPLFKYYKQIVN 449

  Fly   473 AGGRSDVQNYGIGRGGRPCKAAAFLREFVPCGQWMHIDATNVMVTNGIDFE--YLRRGMAGRPTR 535
            .....|:.|.|.|... .|.|||.|...|||.:|.|:|.....:|..|:..  .|:..|.|||||
  Fly   450 KNITYDLCNTGRGPAS-SCLAAAILHTLVPCAEWAHLDIRGTGMTTTINPRPYLLKDSMTGRPTR 513

  Fly   536 TLIEFIAQTIC 546
            |:|:|:.|..|
  Fly   514 TVIQFMYQMAC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S-Lap1	NP_648244.1	PRK00913	44..542	CDD:234863	196/504 (39%)
S-Lap1	NP_648244.1	Peptidase_M17	55..541	CDD:238247	195/492 (40%)
loopin-1	NP_001097338.1	Peptidase_M17	41..518	CDD:238247	195/492 (40%)
loopin-1	NP_001097338.1	PRK00913	43..519	CDD:234863	195/491 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472701
Domainoid	1	1.000	161	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG0260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1544
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D399611at33208
OrthoFinder	1	1.000	-	-		FOG0001058
OrthoInspector	1	1.000	-	-		otm51379
orthoMCL	1	0.900	-	-		OOG6_100682
Panther	1	1.100	-	-	P	PTHR11963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X713
	11	10.800